지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background : Carvedilol is a beta- and alpha-receptor blocker, a direct inhibitor of smooth muscle cell proliferation and migration, and produces a significant suppression of neointimal hyperplasia in rat carotid injury model. We tested whether carvedilol stent coating is effective in preventing neointimal formation in a porcine model of stent restenosis.
Methods : BiodivYsio phosphorylcholine-coated stents were dip-coated with carvedilol at the concentrations of 0, 7, 96 and 154 µg/stent by the immersion in a methanolic carvedilol followed by the evaporation of the solvent. Thirty-two stents, 8 stents per each concentration, were deployed in the porcine coronary arteries. The treatment effect was assessed at 28 days after stent implantation.
Results : Angiographic minimal lumen diameter and late loss index were similar among the four groups. On histomorphometry, neointimal area decreased by 58% and lumen area increased by 20%, resulting in a 58% reduction of percent in-stent stenosis in 7 µg carvedilol/stent (p=0.002, 0.008 and 0.004, respectively, 7 µg vs. 0 µg carvedilol/stent). Modest change in neointimal and lumen area was observed in 96 and 154 µg carvedilol/stent. A proliferating nuclear cell antigen-positive cells was noted 7.78±2.97% in 7 µg carvedilol/stent vs. 17.82±1.45% in 0 µg carvedilol/stent (p=0.0001).
Conclusion : A Low dose carvedilol stent coating produces a significant inhibition of neointimal hyperplasia in a porcine model of stent restenosis. This study provides a potential therapeutic benefit of carvedilol coating in the prevention of human stent restenosis.
목차
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참고문헌 (26)
참고문헌 신청
/ 1992 / Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger 263 : 92 ~ 98
/ 1992 / The restenosis paradigm revisited: an alternative proposal for celullar mechanims 20 : 1284 ~ 1293
/ 1993 / A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease 329 : 221 ~ 227
/ 1993 / Carvedilol inhibits vascular smooth muscle cell proliferation 21 : 221 ~ 227
/ 1993 / Carvedilol. a cardiovascular drug prevents vascular smooth muscle cell proliferation, migration and neointimal formation following vascular injury 90 : 6189 ~ 6193
/ 1992 / The restenosis paradigm revisited: an alternative proposal for celullar mechanims 20 : 1284 ~ 1293
/ 1993 / A comparison of directional atherectomy with coronary angioplasty in patients with coronary artery disease 329 : 221 ~ 227
/ 1993 / Carvedilol inhibits vascular smooth muscle cell proliferation 21 : 221 ~ 227
/ 1993 / Carvedilol. a cardiovascular drug prevents vascular smooth muscle cell proliferation, migration and neointimal formation following vascular injury 90 : 6189 ~ 6193
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