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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 23 - 33 (11page)
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Several studies have shown that curcumin, which is derivedfrom the rhizomes of turmeric, possesses antimicrobial,antioxidant and anti-inflammatory properties. The antitumorproperties of curcumin have also now been demonstratedmore recently in different cancers. This study was undertakento investigate the modulation of cell cycle-related proteins andthe mechanisms underlying apoptosis induction by curcuminin the SCC25 human tongue squamous cell carcinoma cellline. Curcumin treatment of the SCC25 cells resulted in a timeanddose-dependent reduction in cell viability and cell growth,and onset of apoptotic cell death. The curcumin-treatedSCC25 cells showed several types of apoptotic manifestations,such as nuclear condensation, DNA fragmentation, reducedMMP and proteasome activity, and a decreased DNA content.
In addition, the treated SCC25 cells showed a release ofcytochrome c into the cytosol, translocation of AIF andDFF40/CAD into the nuclei, a significant shift in theBax/Bcl-2 ratio, and the activation of caspase-9, caspase-7,caspase-6, caspase-3, PARP, lamin A/C, and DFF45/ICAD.
Furthermore, curcumin exposure resulted in a downregulation of G1 cell cycle-related proteins and upregulation of p27KIP1.
Taken together, our findings demonstrate that curcuminstrongly inhibits cell proliferation by modulating theexpression of G1 cell cycle-related proteins and inducingapoptosis via proteasomal, mitochondrial, and caspasecascades in SCC25 cells.
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참고문헌 (65)
참고문헌 신청
Aggarwal S / 2004 / Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling / Int J Cancer 111:679~692
Fiorillo C / 2008 / Curcumin protects cardiac cells against ischemia-reperfusion injury : effects on oxidative stress, NF-kappaB, and JNK pathways / Free Radic Biol Med 45:839~846
Panicker SR / 2010 / Curcumin attenuates glucoseinduced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factorkappaB pathway / Pharmacology 85:18~26
Chuang SE / 2002 / Basal levels and patterns of anticancer druginduced activation of nuclear factor-kappaB(NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells / Biochem Pharmacol 63:1709~1716
Nakamura K / 2002 / Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines / Int J Oncol 21:825~830
Fiorillo C / 2008 / Curcumin protects cardiac cells against ischemia-reperfusion injury : effects on oxidative stress, NF-kappaB, and JNK pathways / Free Radic Biol Med 45:839~846
Panicker SR / 2010 / Curcumin attenuates glucoseinduced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factorkappaB pathway / Pharmacology 85:18~26
Chuang SE / 2002 / Basal levels and patterns of anticancer druginduced activation of nuclear factor-kappaB(NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells / Biochem Pharmacol 63:1709~1716
Nakamura K / 2002 / Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines / Int J Oncol 21:825~830
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