지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 191 - 196 (6page)
이용수
초록· 키워드
오류제보하기
Transglutaminase2 (TGM2) is a multi-functional calcium dependent enzyme that affects angiogenesis, apoptosis, differentiation, attachment, and changes in the extracellular matrix. However, its function in periodontal tissue has not yet been studied. The aim of this study was to investigate the association of the TGM2 expression and the modulation of inflammatory mediators in inflamed periodontal ligament (PDL) cells induced by pro-inflammatory cytokines such as Interleukin-1β and the Tumor necrosis factor-α. The expression of TGM2 was increased in the inflamed periodontal tissue and PDL cells. Over-expressed TGM2 in the PDL cells increased expression of MMP1, MMP3, IL-6, CXCL8, and PTGS2. Conversely, inhibition of TGM2 activity using LDN27219, a TGM2 inhibitor, resulted in decreased expression of MMP1, MMP3, IL-6, and CXCL8.
The mRNA expression was confirmed by RT-PCR and quantified by qRT-PCR. Protein levels were also confirmed by immunofluoroscence staining. These results suggest that TGM2 plays an important role in the regulation of inflammatory mediators which exacerbate tissue damage in inflamed periodontal tissue.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Alexey M. Belkin / 2011 / Extracellular TG2: emerging functions and regulation / FEBS Journal 278 (24) : 4704 ~ 4716
Beertsen W / 1997 / The periodontal ligament : a unique, multifunctional connective tissue / Periodontol 2000 13 : 20 ~ 40
Chunbo Hao / 2017 / Asiatic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts / International Immunopharmacology 50 : 313 ~ 318
D. Jonsson / 2011 / The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell / Journal of Periodontal Research 46 (2) : 153 ~ 157
Dana Graves / 2008 / Cytokines That Promote Periodontal Tissue Destruction / Journal of Periodontology 79 (8s) : 1585 ~ 1591
Beertsen W / 1997 / The periodontal ligament : a unique, multifunctional connective tissue / Periodontol 2000 13 : 20 ~ 40
Chunbo Hao / 2017 / Asiatic acid inhibits LPS-induced inflammatory response in human gingival fibroblasts / International Immunopharmacology 50 : 313 ~ 318
D. Jonsson / 2011 / The human periodontal ligament cell: a fibroblast-like cell acting as an immune cell / Journal of Periodontal Research 46 (2) : 153 ~ 157
Dana Graves / 2008 / Cytokines That Promote Periodontal Tissue Destruction / Journal of Periodontology 79 (8s) : 1585 ~ 1591
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
뽕잎 n-부탄올 추출물의 치주인대세포에서 LPS로 유도된 염증성 사이토카인의 억제와 골 형성 분화 조절
생약학회지(Korean Journal of Pharmacognosy)
2015 .12
-
Osteoblast differentiation in customized human periodontal ligament cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Periodontal inflamed surface area as a novel numerical variable describing periodontal conditions
Journal of Periodontal & Implant Science
2017 .01
-
Effects of pre-applied orthodontic force on the regeneration of periodontal tissues in tooth replantation
대한치과교정학회지
2019 .09
-
전문가 치주 예방관리 전, 후 치주지수와 치주질환 원인균 발현률 변화
한국구강보건과학회지
2020 .01
-
Expression of TRP calcium channels in human periodontal ligament cells and periodontitis mice
한국실험동물학회 학술발표대회 논문집
2019 .01
-
On the way to world-standard periodontal treatment
Journal of Periodontal & Implant Science
2020 .01
-
치아재식술을 통한 치주 조직 재생의 가능성: 문헌고찰
Oral Biology Research
2015 .01
-
Accuracy of three-dimensional periodontal ligament models generated using cone-beam computed tomography at different resolutions for the assessment of periodontal bone loss
대한치과교정학회지
2023 .03
-
치주치료 후 유지치주치료의 효과에 관한 평가 : 1년 관찰
대한치과의사협회지
2017 .01
-
한국 성인의 대사 증후군이 치주질환에 미치는 영향
한국치위생학회지
2015 .01
-
치주질환 유무에 따른 건강행태와 영양상태
한국치위생학회지
2021 .10
-
3-D Printing Approaches for Periodontal Complex Regeneration : Bone-PDL-Cementum
대한치과재료학회 학술대회
2016 .04
-
스트레스, 수면시간 및 주관적 구강건강 상태가 치주질환에 미치는 영향
보건의료산업학회지
2017 .01
-
Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review
생체재료학회지
2017 .06
-
Effects of Periodontal Treatment on Glycated Hemoglobin A Levels in Patients with Type 2 Diabetes: A Meta-Analysis of Randomized Clinical Trials
치위생과학회지
2018 .01
-
Optimizing the reconstruction filter in cone-beam CT to improve periodontal ligament space visualization: An in vitro study
Imaging science in dentistry
2017 .01
-
노인의 치석제거 인식 및 경험과 치주관리행위의 장애요인
한국구강보건과학회지
2020 .01
-
Improved accuracy in periodontal pocket depth measurement using optical coherence tomography
Journal of Periodontal & Implant Science
2017 .01
-
Relationship between Obesity, Gingival Inflammation, and Periodontal Bacteria after 4-Week Weight Control Program in 20’s
치위생과학회지
2022 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0