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논문 기본 정보

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학술저널
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대한구강생물학회 International Journal of Oral Biology International Journal of Oral Biology 제36권 제3호
발행연도
2011.1
수록면
117 - 122 (6page)

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Endothelial cells are a vital constituent of most mammalian organs and are required to maintain the integrity of these tissues. These cells also play a major role in angiogenesis,inflammatory reactions, and in the regulation of thrombosis. Angiogenesis facilitates pulp formation and produces the vessels which are essential for the maintenance of tooth homeostasis. These vessels can also be used in bone and tissue regeneration, and in surgical procedures to place implants or to remove cancerous tissue. Furthermore, endothelial cell regeneration is the most critical component of the tooth generation process. The aim of the present study was to stimulate endothelial regeneration at a site of acute cyclophosphamide (CP)-induced endothelial injury by treatment with human umbilical cord-derived endothelial/mesenchymal stem cells (hEPCs). We randomly assigned 16 to 20-week-old female NOD/SCID mice into three separate groups, a hEPC (1 ×10^5cells) transplanted, 300mg/kg CP treated and saline (control) group. The mice were sacrificed on days 5 and 10and blood was collected via the abdominal aorta for analysis. The alanine transaminase (ALT), aspartate aminotransferase (AST), serum alkaline phosphatase (s-ALP), and albumin (ALB) levels were then evaluated. Tissue sections from the livers and kidneys were stained with hematoxylin and eosin (HE) for microscopic analysis and were subjected to immunohistochemistry to evaluate any changes in the endothelial layer. CP treatment caused a weight reduction after one day. The kidney/body weight ratio increased in the hEPC treated animals compared with the CP only group at 10 days. Moreover,hEPC treatment resulted in reduced s-ALP, AST, ALT levels compared with the CP only group at 10 days. The CP only animals further showed endothelial injuries at five days which were recovered by hEPC treatment at 10 days. The number of CD31-positive cells was increased by hEPC treatment at both 5 and 10 days. In conclusion, the CP-induced disruption of endothelial cells is recovered by hEPC treatment,indicating that hEPC transplantation has potential benefits in the treatment of endothelial damage.
#human umbilical cord derived endothelial progenitor cell #cyclophosphamide #stem cell transplantation #endothelial injury #regeneration.

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참고문헌 (23)

참고문헌 신청
Anton E / 1997 / Ultrastructural changes of stromal cells of bone marrow and liver after cyclophosphamide treatment in mice / Tissue Cell 29 : 1 ~ 9 google schola Celletti FL / 2001 / Vascular endothelial growth factor enhances atherosclerotic plaque progression / Nat Med 7 : 425 ~ 429 google schola Chai Y / 2003 / Prospects for tooth regeneration in the 21st century: a perspective / Microsc Res Tech 60 : 469 ~ 479 google schola Gronthos S / 2002 / Stem cell properties of human dental pulp stem cells / J Dent Res 81 : 531 ~ 535 google schola Hacking SA / 2009 / Applications of microscale technologies for regenerative dentistry / J Dent Res 88 : 409 ~ 421 google schola

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