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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 97 - 103 (7page)
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초록· 키워드
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The present study investigated the role of peripheral group
I, II, and III metabotropic glutamate receptors (mGluRs) in
mustard oil (MO)-induced nociceptive response in the
masseter muscles of lightly anesthetized rats. Experiments
were carried out on male Sprague-Dawley rats weighing
300-350 gm. After initial anesthesia with sodium pentobarbital
(40 mg/kg, i.p.), one femoral vein was cannulated
and connected to an infusion pump for intravenous infusion
of sodium pentobarbital. The rate of infusion was adjusted
to provide a constant level of anesthesia. MO (30 μL) was
injected into the mid-region of the left masseter muscle via a
30-gauge needle over 10 seconds. After 30 mL injection of
5, 10, 15, or 20% MO into the masseter muscle, total number
of hindpaw-shaking behavior was monitored. Intramuscular
administration of MO significantly produced hindpawshaking
behavior in a dose-dependent manner, as compared
with the vehicle (mineral oil)-treated group. Intramuscular
pretreatment with 10 or 100 ng DHPG, a group I mGluRs
agonist, enhanced MO-induced hindpaw-shaking behavior,
while APDC (20 or 200 μg), a group II mGluRs agonist, or
L-AP4 (2 μg), a group III mGluRs agonist, significantly
reduced MO-induced nociceptive behavior. The antinociception,
produced by group II or III mGluRs agonists, was
abolished by pretreatment with LY341495, a group II
mGluRs antagonist, or CPPG, a group III mGluRs
antagonist, res-pectively. Based on these observations, peripheral
mGluRs differentially modulated MO-induced
nociceptive behavior response in the craniofacial muscle
pain and peripheral group II and III mGluRs agonists could
be used in treatment of craniofacial muscle nociception.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Ahn DK / 2005 / Role of peripheral group I and II metabotropic glutamate receptors in IL-1b-induced mechanical allodynia in the orofacial area of conscious rats / Pain 118 :
Battaglia G / 1997 / In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in r
Bhave G / 2001 / Peripheral group I metabotropic glutamate receptors modulate nociception in mice / Nature?Neuroscience 4 : 417 ~ 423
Carlton SM / 2001 / Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat / Neuroscience 105 : 957 ~ 969
Chen S.R. / 2005 / Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerveinjured rats / Journal of
Battaglia G / 1997 / In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY354740 in r
Bhave G / 2001 / Peripheral group I metabotropic glutamate receptors modulate nociception in mice / Nature?Neuroscience 4 : 417 ~ 423
Carlton SM / 2001 / Localization of metabotropic glutamate receptors 2/3 on primary afferent axons in the rat / Neuroscience 105 : 957 ~ 969
Chen S.R. / 2005 / Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerveinjured rats / Journal of
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