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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 85 - 90 (6page)
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Homeostatic pH is very important for various cellular processes, including metabolism, survival, and death. An imbalanced-pH might induce cellular acidosis, which is involved in many abnormal events such as apoptosis and malignancy. One of several factors contributing to the onset of metabolic acidosis is the production of lactate and protons by lactate dehydrogenase (LDH) in anaerobic glycolysis. LDH is an important enzyme that catalyzes the reversible conversion of pyruvate to lactate. This study sought to examine whether decreases in extracellular pH induce apoptosis of CHO cells, and to elucidate the role of mitogen-activated protein kinases (MAPKs) in acidificationinduced apoptosis. To test apoptotic signaling by acidification we used CHO dhfr- cells that were sensitive to acidification, and CHO/anti-LDH cells that are resistant to acidification-induced apoptosis and have reduced LDH activity by stable LDH antisense mRNA expression. In the present study, cellular lactic acid-induced acidification and the role of MAPKs signaling in acidification-induced apoptosis were investigated. Acidification, which is caused by HCO3 --free conditions, induced apoptosis and MAPKs (ERK, JNK, and p38) activation. However, MAPKs were slightly activated in acidic conditions in the CHO/anti-LDH cells, indicating that lactic acid-induced acidification induces activation of MAPKs. Treatment with a p38 inhibitor, PD169316, increased acidification-induced apoptosis but apoptosis was not affected by inhibitors for ERK (U0126) or JNK (SP600125) Thus, these data support the hypothesis that activation of the p38 MAPK during acidificationinduced apoptosis contributes to cell survival.
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참고문헌 (28)
참고문헌 신청
/ / Single-cell analysis of the intracellular pH and its regulation during the monocytic diferentiation of U937 human leukemic cels : 455 ~ 460
/ 1993 / The mitogen-activated protein kinase signal transduction pathway. 268 : 14553 ~ 14556
/ 1994 / Role of vacuolar adenosine triphosphatase in the regulation of cytosolic pH in hepatocytes : 21 ~ 34
/ 1996 / BCL-2 and MCL-1 expression in Chinese hamster ovary cels inhibits intracellular acidification and apoptosis induced by staurosporine 225 : 430 ~ 436
/ 1996 / Molecular mechanisms of acidosis-mediated damage (66) : 8 ~ 14
/ 1993 / The mitogen-activated protein kinase signal transduction pathway. 268 : 14553 ~ 14556
/ 1994 / Role of vacuolar adenosine triphosphatase in the regulation of cytosolic pH in hepatocytes : 21 ~ 34
/ 1996 / BCL-2 and MCL-1 expression in Chinese hamster ovary cels inhibits intracellular acidification and apoptosis induced by staurosporine 225 : 430 ~ 436
/ 1996 / Molecular mechanisms of acidosis-mediated damage (66) : 8 ~ 14
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