지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 34 - 41 (8page)
이용수
초록· 키워드
오류제보하기
Background: Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action is contended. We determined the effects of flecainide acetate on lipopolysaccharide (LPS)-stimulated human neutrophils in vitro and on mortality in a septic rat model. Methods: Neutrophils from human blood were cultured with varying concentrations of flecainide acetate (1 μM, 10 μM, or 100 μM) with or without LPS (100 ng/ml). To assess neutrophil activation, the protein levels of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 and IL-8 were measured after a 4-hour culture period. To assess the intracellular signaling pathways, the levels of phosphorylation of p38 mitogen-activated protein kinase (p38), extracellular signal-regulated kinase (ERK) 1/2, and c-Jun N-terminal kinase (JNK) were measured after a 30-minute culture period, and the nuclear translocation of nuclear factor (NF)-κB was measured after a 1-hour culture period. Additionally, the survival rate was investigated in a rat sepsis model. Results: Flecainide acetate down-regulated the activation of proinflammatory cytokines, including TNF-α and IL-6 and IL-8, and intracellular signaling pathways including ERK 1/2 and NF-κB. Flecainide acetate also improved the survival rate in the rat sepsis model. Conclusions: Collectively, these findings indicate that flecainide acetate can improve survival in a rat sepsis model by attenuating LPS-induced neutrophil responses. We therefore suggest that flecainide acetate plays an important role in modulating inflammatoryimmune responses.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Ferrer R / 2014 / Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guidelinebased performance improvement program / Crit Care Med 42:1749~1755
Rhee C / 2017 / Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009- 2014 / JAMA 318:1241~1249
van Zanten AR / 2014 / Guideline bundles adherence and mortality in severe sepsis and septic shock / Crit Care Med 42:1890~1898
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock (Sepsis-3) / JAMA 315:801~810
Doerschuk CM / 2000 / CD11/CD18-dependent and -independent neutrophil emigration in the lungs: how do neutrophils know which route to take? / Am J Respir Cell Mol Biol 23:133~136
Rhee C / 2017 / Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009- 2014 / JAMA 318:1241~1249
van Zanten AR / 2014 / Guideline bundles adherence and mortality in severe sepsis and septic shock / Crit Care Med 42:1890~1898
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock (Sepsis-3) / JAMA 315:801~810
Doerschuk CM / 2000 / CD11/CD18-dependent and -independent neutrophil emigration in the lungs: how do neutrophils know which route to take? / Am J Respir Cell Mol Biol 23:133~136
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response
Acute and Critical Care
2016 .01
-
Protective role of curcumin against lipopolysaccharide-induced inflammation and apoptosis in human neutrophil
Anesthesia and Pain Medicine
2020 .01
-
The Effect of Caffeic Acid Phenethyl Ester (CAPE) on Phagocytic activity of septic Neutrophil in vitro
대한의생명과학회지
2023 .12
-
Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation
Korean Journal of Anesthesiology
2020 .01
-
비뇨기암 환자에서 <sup>11</sup>C-Acetate 양전자 방출 컴퓨터 단층 검사 (PET-CT)의 임상 적용
핵의학기술
2016 .01
-
Current Understanding in Neutrophil Differentiation and Heterogeneity
Immune Network
2017 .10
-
[<sup>11</sup>C]아세트산의 방사화학적 수율 증가를 위한 연구
핵의학기술
2018 .01
-
Role of lysophosphatidylcholine in neutrophil-gated immune response during sepsis
한국실험동물학회 학술발표대회 논문집
2022 .01
-
The immunomodulatory effect of Lysophosphatidylcholine (LPC) in LPS-induced septic mouse
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Anti-apoptotic Effects of House Dust Mite, S100A8 and S100A9 on Spontaneous Apoptosis of Neutrophils in Coculture with Immune Cells and in the Presence of T Helper Cytokines
대한의생명과학회지
2015 .06
-
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk
Immune Network
2023 .10
-
Extracellular Vesicles of Neutrophils
Immune Network
2018 .12
-
Warm Acupuncture Reduces Pain and Inflammation in Rats with Lumbar Disc Herniation Induced by Autologous Nucleus Pulposus Transplantation via Regulating p38MAPK/NF-κB Pathway
Journal of Acupuncture & Meridian Studies
2024 .02
-
The therapeutic effect of oleanolic acid acetate on experimental autoimmune encephalomyelitis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Comparison of Anti-Inflammation Effects of Specimens Before and After the Oil Extraction of Raphanus sativus L. Seed in RAW 264.7 Macrophage Activated by LPS
셀메드
2023 .05
-
Current Understanding on the Metabolism of Neutrophils
Immune Network
2020 .12
-
삼백초 Ethyl acetate 분획물의 예쁜꼬마선충 내의 항산화 효과
생약학회지(Korean Journal of Pharmacognosy)
2017 .03
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
Mechanism of helicobacter pylori-Induced IL-1β production in neutrophils
한국실험동물학회 학술발표대회 논문집
2019 .07
-
택사와 alisol B acetate의 병용 투여가 천식 동물 모델에 미치는 영향
대한한방내과학회지
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0