지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 7 - 15 (9page)
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초록· 키워드
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Background: High flow nasal cannula (HFNC) is known to increase global ventilation volume in healthy subjects. We sought to investigate the effect of HFNC on global and regional ventilation patterns in patients with hypoxia. Methods: Patients were randomized to receive one of two oxygen therapies in sequence: nasal cannula (NC) followed by HFNC or HFNC followed by NC. Global and regional ventilation was assessed using electric impedance tomography. Results: Twenty-four patients participated. Global tidal variation (TV) in the lung was higher during HFNC (NC, 2,241 ± 1,381 arbitrary units (AU); HFNC, 2,543 ± 1,534 AU; P < 0.001). Regional TVs for four iso-gravitational quadrants of the lung were also all higher during HFNC than NC. The coefficient of variation for the four quadrants of the lung was 0.90 ± 0.61 during NC and 0.77 ± 0.48 during HFNC (P = 0.035). Within the four gravitational layers of the lung, regional TVs were higher in the two middle layers during HFNC when compared to NC. Regional TV values in the most ventral and dorsal layers of the lung were not higher during HFNC compared with NC. The coefficient of variation for the four gravitational layers of the lung were 1.00 ± 0.57 during NC and 0.97 ± 0.42 during HFNC (P = 0.574). Conclusions: In patients with hypoxia, ventilation of iso-gravitational regions of the lung during HFNC was higher and more homogenized compared with NC. However, ventilation of gravitational layers increased only in the middle layers. (Clinical trials registration number: NCT02943863).
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Slutsky AS / 2014 / Ventilator-induced lung injury / N Engl J Med 370:980
Manley BJ / 2012 / Highflow nasal cannulae for respiratory support of preterm infants: a review of the evidence / Neonatology 102:300~308
Frat JP / 2015 / High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure / N Engl J Med 372:2185~2196
Spoletini G / 2015 / Heated humidified high-flow nasal oxygen in adults: mechanisms of action and clinical implications / Chest 148:253~261
Mundel T / 2013 / Mechanisms of nasal high flow on ventilation during wakefulness and sleep / J Appl Physiol (1985) 114:1058~1065
Manley BJ / 2012 / Highflow nasal cannulae for respiratory support of preterm infants: a review of the evidence / Neonatology 102:300~308
Frat JP / 2015 / High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure / N Engl J Med 372:2185~2196
Spoletini G / 2015 / Heated humidified high-flow nasal oxygen in adults: mechanisms of action and clinical implications / Chest 148:253~261
Mundel T / 2013 / Mechanisms of nasal high flow on ventilation during wakefulness and sleep / J Appl Physiol (1985) 114:1058~1065
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