지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 108 - 114 (7page)
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초록· 키워드
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Background: Acute respiratory failure can occur paradoxically on initiation of anti-tuberculosis (TB) treatment in patients with pulmonary TB. This study is aimed to analyze the clinical features of anti-TB treatment induced acute respiratory failure.
Methods: We reviewed the clinical and radiological characteristics of 8 patients with pulmonary tuberculosis (5 men and 3 women; mean age, 55 ± 15.5 years) who developed acute respiratory failure following initiation of anti- TB medication and thus required mechanical ventilation (MV) in the intensive care unit (ICU).
Results: The interval between initiation of anti-TB medication and development of MV-requiring acute respiratory failure was 2－14 days (mean, 4.4 ± 4.39 days), and the duration of MV was 1－18 days (mean, 7.1 ± 7.03 days). At admission, body temperature and serum levels of lactate dehydrogenase and C-reactive protein were increased. Serum levels of protein, albumin and creatinine were 5.8 ± 0.98, 2.3 ± 0.5 and 1.8 ± 2.58 mg/ml, respectively. Radiographs characterized both lung involvements in all patients. Consolidation with the associated nodule was noted in 7 patients, ground glass opacity in 2, and cavitary lesion in 4. Micronodular lesion in the lungs, suggesting miliary tuberculosis lesion, was noted in 1 patient. At ICU admissions, the ranges of the APACHE II and SOFA scores were 17－38 (mean, 28.2 ± 7.26) and 6－14 (mean, 10.1 ± 2.74). The mean lung injury score was 2.8 ± 0.5. Overall, 6 patients died owing to septic shock and multiorgan failure.
Conclusions: On initiation of treatment for pulmonary TB, acute respiratory failure can paradoxically occur in patients with extensive lung parenchymal involvement and high mortality.
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참고문헌 (16)
참고문헌 신청
Agarwal MK / 1977 / Respiratory failure in pulmonary tuberculosis / Chest 72 : 605 ~ 609
Akira M / 2001 / Clinical and high-resolution computed tomographic findings in five patients with pulmonary tuberculosis who developed respiratory failure following chemothe
Al-Majed SA / 1996 / Study of paradoxical response to chemotherapy in tuberculous pleural effusion / Respir Med 90 : 211 ~ 214
Breen RA / 2004 / Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection / Thorax 59 : 704 ~ 707
Cheng SL / 2007 / Paradoxical response during anti-tuberculosis treatment in HIV-negative patients with pulmonary tuberculosis / Int J Tuberc Lung Dis 11 : 1290 ~ 1295
Akira M / 2001 / Clinical and high-resolution computed tomographic findings in five patients with pulmonary tuberculosis who developed respiratory failure following chemothe
Al-Majed SA / 1996 / Study of paradoxical response to chemotherapy in tuberculous pleural effusion / Respir Med 90 : 211 ~ 214
Breen RA / 2004 / Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection / Thorax 59 : 704 ~ 707
Cheng SL / 2007 / Paradoxical response during anti-tuberculosis treatment in HIV-negative patients with pulmonary tuberculosis / Int J Tuberc Lung Dis 11 : 1290 ~ 1295
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