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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 201 - 206 (6page)
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초록· 키워드
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This study investigated the antimicrobial activity of methanol extract of mulberry leaf against 16 strains of mutans streptococci and four species of periodontopathogens: Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. The antimicrobial activities of the crude extracts or silica gel chromatography fractions of methanol-extracted mulberry leaf were evaluated by determining minimal inhibitory concentrations using an established microdilution method. The cytotoxicity of the extracts of mulberry leaf on KB cells was tested by the methyl thiazolyl tetrazolium assay. Chromatography fraction 12 displayed the most potent antimicrobial activity against all 16 strains of mutans streptococci, P. gingivalis, and P. intermedia. No KB cell cytotoxicity was evident up to 128 μg/ml of fraction 12. The methanol extract had no antimicrobial activity against F. nucleatum and A. actinomycetemcomitans. These results suggest chromatography fraction 12 methanol extract of mulberry leaf could be useful in the development of oral hygiene products, such as dentifrice and oral hygiene solution, for the prevention of dental caries.
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참고문헌 (20)
참고문헌 신청
Asmussen, E. / 1984 / Softening of BISGMA-based polymers by ethanol and by organic acids of plaque / Scand J Dent Res 92 : 257 ~ 261
Darveau RP / 1997 / The microbial challenge in periodontitis / Periodontol 2000 14 : 12 ~ 32
Eo HJ / 2014 / Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark / BMC Complement Altern Med 14 : 200 ~
Haffajee AD / 1994 / Microbial etiological agents of destructive periodontal diseases / Periodontol 2000 5 : 78 ~ 111
Hunyadi A / 2014 / Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity / Nat Prod Commun 9 : 145 ~ 147
Darveau RP / 1997 / The microbial challenge in periodontitis / Periodontol 2000 14 : 12 ~ 32
Eo HJ / 2014 / Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark / BMC Complement Altern Med 14 : 200 ~
Haffajee AD / 1994 / Microbial etiological agents of destructive periodontal diseases / Periodontol 2000 5 : 78 ~ 111
Hunyadi A / 2014 / Volatile glycosides from the leaves of Morus alba with a potential contribution to the complex anti-diabetic activity / Nat Prod Commun 9 : 145 ~ 147
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