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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 193 - 199 (7page)
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Fluoride has been accepted as an important material fororal health and is widely used to prevent dental caries indentistry. However, its safety is still questioned by some.
Autophagy has been implicated in cancer cell survival anddeath, and may play an important role in oral cancer. Thisstudy was undertaken to examine whether sodium fluoride(NaF) modulates autophagy in SCC25 human tonguesquamous cell carcinoma cells. NaF demonstrated anticanceractivity via autophagic and apoptotic cell death. Autophagicvacuoles were detectable using observed to form bymonodansylcadaverine (MDC) and acridine orange (AO).
Analysis of NaF-treated SCC25 cells for the presence ofbiochemical markers revealed direct effects on theconversion of LC-3II, degradation of p62/SQSTM1,cleavage formation of ATG5 and Beclin-1, and caspaseactivation. NaF-induced cell death was suppressed by theautophagy inhibitor 3-methyladenine (3-MA). NaF-inducedautophagy was confirmed as a pro-death signal in SCC25cells. These results implicate NaF as a novel anticancercompound for oral cancer therapy.
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참고문헌 (25)
참고문헌 신청
[학
Anuradha CD / 2000 / Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells / Arch Toxicol 74 : 226 ~ 230
Anuradha CD / 2001 / Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells / Free Radical Bio Med 31 :
Bell RB / 2007 / Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity? / J Oral Maxil Surg 65 : 229 ~ 236
Clayman GL / 1997 / Report of the Tenth International Symposium of the Foundation for Promotion of Cancer Research : Basic and clinical research in head and neck cancer / Jp
Anuradha CD / 2000 / Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells / Arch Toxicol 74 : 226 ~ 230
Anuradha CD / 2001 / Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells / Free Radical Bio Med 31 :
Bell RB / 2007 / Tongue cancer: Is there a difference in survival compared with other subsites in the oral cavity? / J Oral Maxil Surg 65 : 229 ~ 236
Clayman GL / 1997 / Report of the Tenth International Symposium of the Foundation for Promotion of Cancer Research : Basic and clinical research in head and neck cancer / Jp
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