지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 51 - 57 (7page)
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초록· 키워드
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Runx2 and Osterix, the transcription factors for osteoblast differentiation, are known as fundamental factors to regulate the development of calcified tissues. However, the biological functions of these factors in the development of the periodontal tissues remain unclear. In this study, we investigated the distribution of Runx2 and Osterix during periodontal tissue development of the mice. Mandibles from 14-day-old mice were prepared for paraffin section. Serial sections of the mandible containing 1st molar tooth germs were obtained as a thickness of 7 μm. Some sections were stained with hematoxylin and eosin. Others were used for immunohistochemistry for PCNA, Runx2, and Osterix. Epithelial cells in growing end of Hertwig’s epithelial root sheath (HERS) and mesenchymal cells adjacent to the growing end of HERS expressed PCNA.
Undifferentiated mesenchymal cells and hard tissue forming cells like cementoblasts and osteoblasts in early stage of differentiation expressed Runx2. Fully differentiated cementoblasts and osteoblasts secreting matrix proteins expressed Osterix.
However, the cells terminated the matrix formation did not express Osterix. Periodontal ligament cells expressed Runx2and Osterix. Pulp cells expressed Runx2 only.These results suggest that Runx2 and Osterix might regulate the differentiation of cementoblasts in the same manner as osteoblasts.
Runx2 might participate in the process of cementoblast differentiation in early stage, whether Osterix might regulate the maturation and matrix synthesis of the cells.
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참고문헌 (22)
참고문헌 신청
Aberg T / 2004 / Phenotypic changes in dentition of Runx2 homozygote-null mutant mice / J Histochem Cytochem 52 : 131 ~ 139
Aberg T / 2004 / Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis / Dev Biol 270 : 76 ~ 93
Bosshardt DD / 2005 / Are cementoblasts a subpopulation of osteoblasts or a unique phenotype / J Dent Res 84 : 390 ~ 406
D'Errico JA / 1997 / Expression of bone associated markers by tooth root lining cells, in situ and in vitro / Bone 20 : 117 ~ 126
D'Errico JA / 2000 / Employing a transgenic animal model to obtain cementoblasts in vitro / J Periodontol 71 : 63 ~ 72
Aberg T / 2004 / Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis / Dev Biol 270 : 76 ~ 93
Bosshardt DD / 2005 / Are cementoblasts a subpopulation of osteoblasts or a unique phenotype / J Dent Res 84 : 390 ~ 406
D'Errico JA / 1997 / Expression of bone associated markers by tooth root lining cells, in situ and in vitro / Bone 20 : 117 ~ 126
D'Errico JA / 2000 / Employing a transgenic animal model to obtain cementoblasts in vitro / J Periodontol 71 : 63 ~ 72
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