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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 165 - 168 (4page)
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초록· 키워드
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Postantibiotic effect (PAE) is defined as the length of time
that bacterial growth is suppressed following brief exposure
to an antibiotic. In this study, the in vitro PAE, postantibiotic
sub-MIC effect (PA SME) and sub-MIC effect (SME) of
antibiotics on Treponema denticola ATCC 35405 were
investigated. The PAE of doxycycline and metronidazole
were 20.3 h and 25.0 h, respectively. The PA SMEs examined
by addition of 0.1, 0.2 and 0.3X MICs during the postantibiotic
phase of the bacteria for metronidazole were longer
than those for doxycycline. In contrast, the SMEs for doxycycline
were longer than those for metronidazole. The PA
SME and SME values increased as the concentration of
antibiotics increased. The present study illustrates the
existence of PAE, PA-SME and SME for several antibiotics
against T. denticola, thereby extending the pharmacodynamic
advantages of these antibiotics.
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참고문헌 (15)
참고문헌 신청
Gudmundsson S / 1993 / Erlendsdottir H, Moffat J, Bayer W, Craig WA. The post-antibiotic effect of antimicrobial combinations in a neutropenic murine thigh infection model /
Haapasalo M / 1991 / Sulfhydryldependent attachment of Treponema denticola to laminin and other proteins / Infect Immun 59 : 4230 ~ 4237
Lee SY / 2000 / Postantibiotic effects and postantibiotic sub-MIC effects of amoxicillin on Streptococcus gordonii and Streptococcus sanguis / J Chemother 12 : 379 ~ 384
Lee SY / 2004 / Penicillin-induced killing and postantibiotic effect in oral streptococci are enhanced by platelet microbicidal proteins / Int J Antimicrob Agents 23 : 457 ~
Li RC / 1997 / Correlation between bactericidal activity and postantibiotic effect for five antibiotics with different mechanisms of action / J Antimicrob Chemother 40 : 39 ~
Haapasalo M / 1991 / Sulfhydryldependent attachment of Treponema denticola to laminin and other proteins / Infect Immun 59 : 4230 ~ 4237
Lee SY / 2000 / Postantibiotic effects and postantibiotic sub-MIC effects of amoxicillin on Streptococcus gordonii and Streptococcus sanguis / J Chemother 12 : 379 ~ 384
Lee SY / 2004 / Penicillin-induced killing and postantibiotic effect in oral streptococci are enhanced by platelet microbicidal proteins / Int J Antimicrob Agents 23 : 457 ~
Li RC / 1997 / Correlation between bactericidal activity and postantibiotic effect for five antibiotics with different mechanisms of action / J Antimicrob Chemother 40 : 39 ~
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