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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 13 - 19 (7page)
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Various voltage-gated K+ currents were recently described in dorsal root ganglion (DRG) neurons. However, the characterization and diversity of voltage-gated K+ currents have not been well studied in trigeminal root ganglion (TRG)neurons, which are similar to the DRG neurons in terms of physiological roles and anatomy. This study was aimed to investigate the characteristics and diversity of voltage-gated K+ currents in acutely isolated TRG neurons of rat using whole cell patch clamp techniques. The first type (type I) had a rapid, transient outward current (IA) with the largest current size having a slow inactivation rate and a sustained delayed rectifier outward current (IK) that was small in size having a fast inactivation rate. The IA currents of this type were mostly blocked by TEA and 4-AP, K channel blockers whereas the IK current was inhibited by TEA but not by 4-AP. The second type had a large IA current with a slow inactivation rate and a medium size-sustained delayed IK current with a slow inactivation rate. In this second type (type II), the sensitivities of the IA or IK current by TEA and 4-AP were similar to those of the type I. The third type (type III) had a medium sized IA current with a fast inactivation rate and a large sustained IK current with the slow inactivation rate. In type III current, TEA decreased both IA and IK but 4-AP only blocked IA current. The fourth type (type IV) had a smallest IA with a fast inactivation rate and a large IK current with a slow inactivation rate. TEA or 4-AP similarly decreased the IA but the IK was only blocked by 4-AP. These findings suggest that at least four different voltage-gated K+ currents in biophysical and pharmacological properties exist in the TRG neurons of rats.
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참고문헌 (23)
참고문헌 신청
Adams DJ / 1983 / Interaction of internal anions with potassium channels of the squid giant axon / The Journal of general physiology 82 (4) : 429 ~ 448
Akins PT / 1993 / Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP / Neuroscience 56 (3) : 759 ~ 769
Akopian AN / 1996 / A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons / Nature 379 (6562) : 257 ~ 262
Caffrey JM / 1992 / Three types of sodium channels in adult rat dorsal root ganglion neurons / Brain Res 592 (1-2) : 283 ~ 297
Connor JA / 1971 / Voltage clamp studies of a transient outward membrane current in gastropod neural somata / The Journal of physiology 213 (1) : 21 ~ 30
Akins PT / 1993 / Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP / Neuroscience 56 (3) : 759 ~ 769
Akopian AN / 1996 / A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons / Nature 379 (6562) : 257 ~ 262
Caffrey JM / 1992 / Three types of sodium channels in adult rat dorsal root ganglion neurons / Brain Res 592 (1-2) : 283 ~ 297
Connor JA / 1971 / Voltage clamp studies of a transient outward membrane current in gastropod neural somata / The Journal of physiology 213 (1) : 21 ~ 30
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