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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 37 - 42 (6page)
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Receptor activator of NF-κB ligand (RANKL) is an essential cytokine for osteoclast differentiation, activation and survival. T lymphocytes such as T17 cells, a subset of T helper cells that produce IL-17, play an important role in rheumatoid arthritic bone resorption by producing inflammatory cytokines and RANKL. It has not yet been clearly elucidated how T cell activation induces RANKL expression. T cell receptor activation induces the activation of nuclear factor of activated T cell (NFAT) and expression of its target genes.
In this study, we examined the role of NFAT in T cell activation-induced RANKL expression. EL-4, a murine T lymphocytic cell line, was used. When T cell activation was induced by phorbol 12-myristate 13-acetate (PMA) and ionomycin,RANKL expression increased in a time-dependent manner. In the presence of cyclosporin, an inhibitor of NFAT activation, this PMA/ionomycin‐induced RANKL expression was blocked. Overexpression of either NFATc1 or NFATc3 induced RANKL expression. Chromatin immunoprecipitation results demonstrated that PMA/ionomycin treatment induced the binding of NFATc1 and NFATc3 to the mouse RANKL gene promoter. These results suggest that NFATc1 and NFATc3 mediates T cell receptor activationinduced RANKL expression in T lymphocytes.
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참고문헌 (29)
참고문헌 신청
Liu J / 1991 / Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes / Cell 66:807~815
O'Keefe SJ / 1992 / FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin / Nature 357:692~694
Pinkas-Kramarski R / 1990 / Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines / Neurosci Lett 108:335~340
Okamoto K / 2011 / Osteoclasts in arthritis and Th17 cell development / Int Immunopharmacol 11:543~548
Borel JF / 1976 / Biological effects of cyclosporin A: a new antilymphocytic agent / Agents Actions 6 : 468 ~ 475
O'Keefe SJ / 1992 / FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin / Nature 357:692~694
Pinkas-Kramarski R / 1990 / Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines / Neurosci Lett 108:335~340
Okamoto K / 2011 / Osteoclasts in arthritis and Th17 cell development / Int Immunopharmacol 11:543~548
Borel JF / 1976 / Biological effects of cyclosporin A: a new antilymphocytic agent / Agents Actions 6 : 468 ~ 475
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