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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 81 - 86 (6page)
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SET (Suppressor of variegation, Enhancer of zeste, and the Trithorax) domain-containing proteins are known to have methyltransferase activity at lysine residues of histone proteins. In this study, we identified a novel SET domain-containing protein from mouse and named Kodo7. Indeed, Kodo7 has methyltransferase activity at K9 residue of the H3 protein as demonstrated by a histone methyl-transferse activity assay using GST-tagged Kodo7. Confocal microscopy showed that Kodo7 is co-localized with histones in the nucleus. Interestingly, ectopic expression of Kodo7 by transient transfection induced cell death and treatment of the transfectants with a caspase-3 inhibitor, Ac-DEVD-AFC decreased Kodo7-induced apoptosis. These results suggest that Kodo7 induces apoptotic cell death through increased methylation of histones leading to transcriptional repression.
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참고문헌 (23)
참고문헌 신청
/ 1993 / The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax : 6357 ~ 66
/ 1994 / The protein encoded by the Drosophila position-effect variegation suppressor gene Su 3-9 combines domains of antagonistic regulators of homeotic gene complexes : 38
/ 1995 / The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal
/ 1997 / Crystal structure of the nucleosome core particle at 2.8 A resolution 389 : 251 ~ 260
/ 1997 / Disruption of a homolog of trithorax by 11q23 translocations 220 : 1 ~ 23
/ 1994 / The protein encoded by the Drosophila position-effect variegation suppressor gene Su 3-9 combines domains of antagonistic regulators of homeotic gene complexes : 38
/ 1995 / The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal
/ 1997 / Crystal structure of the nucleosome core particle at 2.8 A resolution 389 : 251 ~ 260
/ 1997 / Disruption of a homolog of trithorax by 11q23 translocations 220 : 1 ~ 23
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