지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 9 - 16 (8page)
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초록· 키워드
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The aim of this study was to evaluate surface characteristics and biological properties of the dentin -derived hydroxyapatite (HA) coating on titanium substrate. Dentinderived HA was obtained from extracted human teeth using a calcination method at 850oC. The commercially pure titanium (cp-Ti, ASTM Grade II) was used as a metallic substrate and a radio frequency magnetron sputtering method was employed as a coating method. Scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX) were utilized to investigate the coating aspects and composition. Atomic forced microscopy (AFM)and a surface profiler were used to assess the surface morphology and roughness. Corrosion tests were performed in phosphate- buffered saline at a 36.5 ± 1oC in order to determine the corrosion behavior of the uncoated and coated specimens. The biocompatibility of dentin-derived HA coated specimens with fetal rat calvarial cells and human gingival fibroblasts was assessed by SEM and cell proliferation analysis. The results showed that the dentin-derived HA coatings appeared to cover thinly and homogeneously the surfaces without changing of the titanium substrate. The EDX analysis of this the coating surface indicated the presence of Ca and P elements. The mean surface roughness of cp-Ti and dentin-derived coating specimens was 0.27 μm and, 1.7 μm, respectively. Corrosion tests indicated a stable passive film of the dentin-derived HA coating specimens.
SEM observations of fetal rat calvarial cells and human fibroblast cells on coated surfaces showed that the cells proliferated and developed a network of dense interconnections.
The cells on all specimens proliferated actively within the culture period, showing good cell viability. At day 1 and 3, dentin-derived coating specimens showed 89% and 93%cell viability, respectively, when normalized to cp-Ti specimens. These results suggest that dentin-derived HA coating using the RF magnetron sputtering method has good surface characteristics and biocompatibility.
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참고문헌 (23)
참고문헌 신청
Albrektsson T / 1981 / Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man / Acta Orthop Scand 52 : 155 ~ 170
Deporter DA / 1986 / A histological assessment of the initial healing response adjacent to porous-surfaced, titanium alloy dental implants in dogs / J Dent Res 65 : 1064 ~ 10
Forsgren J / 2007 / Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates / Acta Biomater 3 : 980 ~ 984
Glauser R / 2001 / Initial implant stability using different implant designs and surgical techniques / Applied Osseointegration Research 2 : 6 ~ 8
Goller G / 2004 / Plasma-sprayed human bone-derived hydroxyapatite coatings: effective and reliable / J Materials Letters 58 : 2599 ~ 2604
Deporter DA / 1986 / A histological assessment of the initial healing response adjacent to porous-surfaced, titanium alloy dental implants in dogs / J Dent Res 65 : 1064 ~ 10
Forsgren J / 2007 / Formation and adhesion of biomimetic hydroxyapatite deposited on titanium substrates / Acta Biomater 3 : 980 ~ 984
Glauser R / 2001 / Initial implant stability using different implant designs and surgical techniques / Applied Osseointegration Research 2 : 6 ~ 8
Goller G / 2004 / Plasma-sprayed human bone-derived hydroxyapatite coatings: effective and reliable / J Materials Letters 58 : 2599 ~ 2604
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