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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 211 - 216 (6page)
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초록· 키워드
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Nitric Oxide (NO) is an important signaling molecule in the nociceptive process. Our previous study suggested that high concentrations of sodium nitroprusside (SNP), a NO donor, induce a membrane hyperpolarization and outward current through large conductances calcium-activated potassium (BKca) channels in substantia gelatinosa (SG) neurons. In this study, patch clamp recording in spinal slices was used to investigate the sources of Ca²+ that induces Ca²+-activated potassium currents. Application of SNP induced a membrane hyperpolarization, which was significantly inhibited by hemoglobin and 2-(4-carboxyphenyl) -4,4,5,5- tetramethylimidazoline-1-oxyl-3-oxide potassium salt (c-PTIO), NO scavengers. SNP-induced hyperpolarization was decreased in the presence of charybdotoxin, a selective BKCa channel blocker. In addition, SNP-induced response was significantly blocked by pretreatment of thapsigargin which can remove Ca²+ in endoplasmic reticulum, and decreased by pretreatment of dentrolene, a ryanodine receptors (RyR) blocker. These data suggested that NO induces a membrane hyperpolarization through BKca channels, which are activated by intracellular Ca²+ increase via activation of RyR of Ca²+ stores.
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참고문헌 (22)
참고문헌 신청
Ahern GP / 2002 / cGMP and S-nitrosylation: two routes for modulation of neuronal excitability / NO. Trends in Neurosci 25 : 510 ~ 517
B-N Wu / 2007 / Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes / British Journal of Pha
Cheng LZ / 2010 / Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice / Mol Pain 6 : 1 ~ 12
Coderre TJ / 1994 / Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model / E
Coskun S / 2005 / The effect of L-NAME administrations after oral mucosal incision on wound NO level in rabbit / Mol Cellular Biochem 278 : 65 ~ 69
B-N Wu / 2007 / Activation of BKCa channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes / British Journal of Pha
Cheng LZ / 2010 / Ryanodine receptors contribute to the induction of nociceptive input-evoked long-term potentiation in the rat spinal cord slice / Mol Pain 6 : 1 ~ 12
Coderre TJ / 1994 / Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model / E
Coskun S / 2005 / The effect of L-NAME administrations after oral mucosal incision on wound NO level in rabbit / Mol Cellular Biochem 278 : 65 ~ 69
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