지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 194 - 201 (8page)
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초록· 키워드
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Background: The study on bacteremia helps empirically select the proper antibiotics before the results of culture test about causative pathogen. The purpose of this study is to investigate causative pathogen in bloodstream infection, changing aspects based on elapsed time after burn, relationship with other sites and resistance of important causative pathogen against antibiotics through analysis on bacteria isolated from blood culture of patients hospitalized in burn intensive care unit (BICU).
Materials and Methods: A retrospective study was conducted targeting patients hospitalized in BICU from January 2007 to June 2011. Changes of causative pathogen in bloodstream infection based on elapsed time after injury were analyzed. We would like to examine the relationship between bloodstream infection and infection on other body parts by comparing results of cultures in burn wound site, sputum, urine and catheter tip. Antibiotics resistance patterns of Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus species, and Klebsiella pneumoniae were studied.
Results: A total of 2,337 burn patients were hospitalized in BICU for 54 months. Causative pathogen was cultured in blood cultures from 397 patients (17.0%). P. aeruginosa (169, 30.1%) was the most cultured and A. baumannii (107, 19.0%) and S.
aureus (81, 14.4%) were followed. It was confirmed that the relative frequency of A. baumannii tended to get lower as the period got longer after injury, but the relative frequency of K. pneumoniae got higher as the period got longer after injury. With comparison without bacteremia, P. aeruginosa bacteremia showed high probability in which the same bacteria were cultured in wound site, sputum and cathether tip, and A. baumannii bacteremia and candida bacteremia had high probability in sputum,and urine and catheter tip, respectively. 95.9% of P. aeruginosa and 95.3% of A. baumannii showed the resistance against carbapenem.
96.3% of S. aureus was methicillin resistant and 36.2% of Enterococcus species were vancomycin resistant. 75.0%of K. pneumonia were extended-spectrum beta-lactamase (ESBL)-producing bacteria.
Conclusions: Since the highly antibiotic resistant microorganisms were isolated from the patients hospitalized in BICU during early phase, the empirical selection of antibiotics targeting these pathogens should be considered before the results of microbiologic culture test. In addition, use of empirical antifungal agent after 1 week of injury can be considered for patients who have risk factor of fungal infection.
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참고문헌 (16)
참고문헌 신청
Altoparlak U / 2004 / Thetime-related changes of antimicrobial resistance patternsand predominant bacterial profiles of burn wounds andbody flora of burned patients / Burns 3
Ballard J / 2008 / Multicenter Trials Group, American Burn Association.Positive fungal cultures in burn patients: a multicenter review / J Burn Care Res 29 : 213 ~ 221
Chong SJ / 2011 / 5 year analysisof bacteriology culture in a tropical burns ICU / Burns 37 : 1349 ~ 1353
Gang RK / 2000 / Staphy lococcalsepticaemiain burns / Burns 26 : 359 ~ 366
Henwood CJ / 2000 / Susceptibility of gram-positive coccifrom 25 UK hospitals to antimicrobial agents including linezolid.The Linezolid Study Group / J Antimicrob Chemother 4
Ballard J / 2008 / Multicenter Trials Group, American Burn Association.Positive fungal cultures in burn patients: a multicenter review / J Burn Care Res 29 : 213 ~ 221
Chong SJ / 2011 / 5 year analysisof bacteriology culture in a tropical burns ICU / Burns 37 : 1349 ~ 1353
Gang RK / 2000 / Staphy lococcalsepticaemiain burns / Burns 26 : 359 ~ 366
Henwood CJ / 2000 / Susceptibility of gram-positive coccifrom 25 UK hospitals to antimicrobial agents including linezolid.The Linezolid Study Group / J Antimicrob Chemother 4
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