지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 76 - 84 (9page)
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Background: Even after pneumococcal vaccination introduction, Streptococcus pneumoniae (pneumoccocus) is still an important cause of respiratory and invasive severe infection. Pneumococcus is resided in nasal mucosa and local or systemic infection begins with the nasal mucosa damage. We studied the indirect effect of pneumococcal conjugate vaccine (PCV) on pneumococcal nasopharyngeal carriage rates, serotypes and antimicrobial susceptibility between vaccinate and non-vaccinated children.
Materials and Methods: From January 2010 to October 2010, 379 healthy children under 5 years old from three university hospitals were recruited. Fully vaccinated children over 3 time doses of PCV and children with no vaccination history of PCV were enrolled, and nasopharyngeal aspirations were obtained from these children. Serotypes using multibead serotyping assay with multiplex PCR and antimicrobial susceptibility was analyzed. Antimicrobial susceptibilities were determined by the CLIS guideline.
Results: Two hundred seventy six children were received pneumococcal vaccination while 103 were not. 137 pneumococci were isolated from nasopharyngeal aspiration specimens. Nasal carriage rate was significantly low in vaccinated group (P -value;0.001). Nasopharyngeal carriage rate was 28.6% (79/276) in vaccinate group and 56.3% (58/103) in non-vaccinated group.
Among those vaccinated group, 13.0% (36/276) of the serotypes were vaccine or vaccine related type with the most common type 19F. In contrast, 31.1% (32/103) of the serotypes in non vaccinated group were vaccine or vaccine related type with the most common type 6A. The resistant rate of penicillin was 90.5%. For antimicrobial susceptibility, amoxicillin and amoxicillin/clavulanate showed high susceptibility (73.0%), but 19F and 19A serotypes were all resistant against amoxicillin.
Conclusions: High nasopharyngeal carriage rate in non vaccinated group corresponded to the result of past study. However,19F and 19A still came up as problematic serotypes with a high carriage rate and antimicrobial resistance in both vaccinated and non vaccinated groups. Also, this study showed that the resistance rate of primary oral antimicrobial agents was increased in compared to past. For solving these problems, the selective antimicrobial use with establishment of high dose amoxicillin/clavulanate regimen and active PCV immunization should be needed. Furthermore, pneumococcal carriage and serotype study concerning with antimicrobial susceptibility should be conducted in the future in 10 or 13-valent PCV received children.
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참고문헌 (22)
참고문헌 신청
/ 1999 / Trends in the antimicrobial susceptibility of bacterial respiratorytract pathogens--findings of the Alexander Project1992-1996 / J Chemother 11 (1) : 5 ~ 21
Charpentier E / 2000 / Mechanisms of antibioticresistance and tolerance in Streptococcus pneumoniae / MicrobesInfect 2 : 1855 ~ 1864
Clinical and Laboratory Standards Instit / 2010 / Streptococcuspneumoniae. In: Performance standards for antimicrobialsusceptibility testing; twentieth informational supplement.Docume
Craig WA / 1998 / Pharmacokinetic/pharmacodynamic parameters:rationale for antibacterial dosing of mice and men / ClinInfect Dis 26 : 1 ~ 10
Cunha BA / 2003 / Penicillin resistance in pneumococcal pneumonia.Antibiotics with low resistance potential are effectiveand pose less risk / Postgrad Med 113 : 42 ~ 54
Charpentier E / 2000 / Mechanisms of antibioticresistance and tolerance in Streptococcus pneumoniae / MicrobesInfect 2 : 1855 ~ 1864
Clinical and Laboratory Standards Instit / 2010 / Streptococcuspneumoniae. In: Performance standards for antimicrobialsusceptibility testing; twentieth informational supplement.Docume
Craig WA / 1998 / Pharmacokinetic/pharmacodynamic parameters:rationale for antibacterial dosing of mice and men / ClinInfect Dis 26 : 1 ~ 10
Cunha BA / 2003 / Penicillin resistance in pneumococcal pneumonia.Antibiotics with low resistance potential are effectiveand pose less risk / Postgrad Med 113 : 42 ~ 54
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