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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 32 - 43 (12page)
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Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published.
The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis,echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis,and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried.
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참고문헌 (24)
참고문헌 신청
Andrews P / 1983 / Praziquantel / Medl Res Rev 3 : 147 ~ 200
Becker B / 1980 / Lightand electron microscopic studies on the effect of praziquantelon Schistosoma mansoni, Dicrocoelium dendriticum,and Fasciola hepatica (Trematoda) in vi
Becker B / 1980 / Thomas H. Scanning andtransmission electron microscope studies on the efficacyof praziquantel on Hymenolepis nana (Cestoda) in vitro / ZParasikentd 61 : 12
Becker B / 1981 / Ultrastructuralinvestigations on the effect of praziquantel on the tegument of five species of cestodes / Z Parasikentd 64 : 257 ~ 269
Bylund G / 1977 / Tests with a new compound(Praziquantel) against Diphyllobothrium latum / J Helminthol 51 : 115 ~ 119
Becker B / 1980 / Lightand electron microscopic studies on the effect of praziquantelon Schistosoma mansoni, Dicrocoelium dendriticum,and Fasciola hepatica (Trematoda) in vi
Becker B / 1980 / Thomas H. Scanning andtransmission electron microscope studies on the efficacyof praziquantel on Hymenolepis nana (Cestoda) in vitro / ZParasikentd 61 : 12
Becker B / 1981 / Ultrastructuralinvestigations on the effect of praziquantel on the tegument of five species of cestodes / Z Parasikentd 64 : 257 ~ 269
Bylund G / 1977 / Tests with a new compound(Praziquantel) against Diphyllobothrium latum / J Helminthol 51 : 115 ~ 119
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