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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국자기공명학회 Journal of the Korean Magnetic Resonance Society Journal of the Korean Magnetic Resonance Society 제17권 제1호
- 발행연도
- 2013.1
- 수록면
- 40 - 46 (7page)
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초록· 키워드
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For a case study of suspected paraquatintoxication, we developed a simple and rapidmethod of 1H qNMR to determine the mili-molaramount of paraquat in postmortem blood samples.
There were no interfering signals from endogenouscompounds in the chemical shift of paraquat anddiquat (internal standard). The amount of sampleused ranged from 0.25 mM to 10.0 mM. Diquat,which has similar physicochemical properties withparaquat, was chosen as an internal standard. TheNMR experimental conditions, relaxation delay timeand CPMG spin-echo pulse sequence were optimized.
The developed method was validated in terms ofspecificity, accuracy, precision, matrix effect,recovery, limit of detection (LOD), and low limit ofquantification (LLOQ). The proposed qNMR methodprovided a simple and rapid assay for theidentification and quantification of the quaternaryammonium herbicide, “paraquat” in postmortemblood samples. This method was tested by using theblood from the heart of a man who was intoxicatedwith paraquat. In this particular case, the level ofparaquat was 1.07 mM in the blood. For thedetermination of quaternary ammonium herbicides,qNMR could also be used to provide a betterunderstanding of the currently available techniques.
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