지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 219 - 225 (7page)
이용수
초록· 키워드
오류제보하기
Although antibiotics whose epithelial lining fluid (ELF) concentrations are reported high tend to be preferred in treatment ofpneumonia, measurement of ELF concentrations of antibiotics could be misled by contamination from lysis of ELF cells andtechnical errors of bronchoalveolar lavage (BAL). In this review, ELF concentrations of anti-methicillin resistant Staphylococcusaureus (MRSA) antibiotics were interpreted considering above confounding factors. An equation used to explain antibiotic diffusioninto CSF (cerebrospinal fluid) was adopted: ELF/free serum concentration ratio = 0.96 + 0.091 × ln (partition coefficient/ molecular weight1/2). Seven anti-MRSA antibiotics with reported ELF concentrations were fitted to this equation to see if theirELF concentrations were explainable by the penetration capacity only. Then, outliers were modeled under the assumption ofvarying contamination from lysed ELF cells (test range 0-10% of ELF volume). ELF concentrations of oritavancin, telavancin,tigecycline, and vancomycin were well described by the diffusion equation, with or without additional impact from cell lysis.
For modestly high ELF/free serum concentration ratio of linezolid, technical errors of BAL should be excluded. Although teicoplaninand iclaprim showed high ELF/free serum ratios also, their protein binding levels need to be cleared for proper interpretation.
At the moment, it appears very premature to use ELF concentrations of anti-MRSA antibiotics as a relevant guide fortreatment of lung infections by MRSA.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Hutschala D / 2005 / In vivo measurement of levofloxacin penetration into lung tissue after cardiac surgery / Antimicrob Agents Chemother 49:5107~5111
Tomaselli F / 2003 / Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis / Br J Clin Pharmacol 55:620~624
Zeitlinger MA / 2007 / A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung / Int J Antimicrob Agents 29:44~50
Forrest A / 1993 / Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients / Antimicrob Agents Chemother 37:1073~1081
Moise PA / 2000 / Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus / Am J Health Syst Pharm 57(Suppl 2):S4~S9
Tomaselli F / 2003 / Penetration of piperacillin and tazobactam into pneumonic human lung tissue measured by in vivo microdialysis / Br J Clin Pharmacol 55:620~624
Zeitlinger MA / 2007 / A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung / Int J Antimicrob Agents 29:44~50
Forrest A / 1993 / Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients / Antimicrob Agents Chemother 37:1073~1081
Moise PA / 2000 / Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus / Am J Health Syst Pharm 57(Suppl 2):S4~S9
이 논문의 저자 정보
최근 본 자료
댓글(0)
0