지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 74 - 80 (7page)
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초록· 키워드
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Background: Abnormal serum gamma-glutamyltransferase (γ-GT) may be an early and sensitive marker for oxidative stress. This study was performed to evaluate the association between serum heavy metals and γ-GT concentration.Methods: This study is a cross-sectional analysis based on data from Korean National Health and Nutrition Examination Survey (V-1, 2, 2010, 2011) regarding serum heavy metal concentrations (lead, mercury, and cadmium) as well as serum γ-GT. Serum heavy metals were categorized into tertiles, and serum γ-GT concentration was compared using an analysis of covariance test after relevant variable adjustments. In addition, we evaluated the odds ratio (OR) of having the highest tertile of serum γ-GT in each heavy metal tertile using logistic regression.Results: The mean serum lead, mercury, and cadmium concentrations were 2.67, 5.08, and 1.02 μg/dL in men and 1.95, 3.60, and 1.21 μg/dL in women, respectively. Partial correlation showed a significant positive relation between each heavy metal and serum γ-GT concentration. Comparing serum γ-GT concentration by the tertile of each heavy metal, serum γ-GT concentration showed a significant increase as the tertiles of serum mercury and cadmium in men and that of serum mercury in women increased, but not with lead. The OR of having the highest tertile of serum γ-GT was significant for cadmium in men (OR, 4.02; 95% confidence interval [CI], 2.54 to 6.35) and mercury in women (OR, 2.00; 95% CI, 1.29 to 3.10) in the top tertile of each heavy metal.Conclusion: Higher serum heavy metal concentration may be related with higher serum γ-GT concentration. In particular, serum cadmium in men and mercury in women showed significant correlation with serum γ-GT concentration.
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참고문헌 (21)
참고문헌 신청
Adamis PD / 2009 / Glutathione and gamma-glutamyl transferases are involved in the formation of cadmium-glutathione complex / FEBS Lett 583 : 1489 ~ 1492
Al-Neamy FR / 2001 / Occupational lead exposure and amino acid profiles and liver function tests in industrial workers / Int J Environ Health Res 11 : 181 ~ 188
Alfven T / 2000 / Low-level cadmium exposure and osteoporosis / J Bone Miner Res 15 : 1579 ~ 1586
Cederbaum AI / 2001 / Introduction-serial review: alcohol, oxidative stress and cell injury / Free Radic Biol Med 31 : 1524 ~ 1526
Centers for Disease Control and Prevention / / Fact sheet: the fourth national report on human exposure to environmental chemicals, 2009 (US) [Internet]
Al-Neamy FR / 2001 / Occupational lead exposure and amino acid profiles and liver function tests in industrial workers / Int J Environ Health Res 11 : 181 ~ 188
Alfven T / 2000 / Low-level cadmium exposure and osteoporosis / J Bone Miner Res 15 : 1579 ~ 1586
Cederbaum AI / 2001 / Introduction-serial review: alcohol, oxidative stress and cell injury / Free Radic Biol Med 31 : 1524 ~ 1526
Centers for Disease Control and Prevention / / Fact sheet: the fourth national report on human exposure to environmental chemicals, 2009 (US) [Internet]
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