지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국자기공명학회 Journal of the Korean Magnetic Resonance Society Journal of the Korean Magnetic Resonance Society 제18권 제1호
- 발행연도
- 2014.1
- 수록면
- 10 - 14 (5page)
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초록· 키워드
오류제보하기
Hsp90 is a good drug target molecule that is involved in regulating various signaling pathway in normal cell and the role of Hsp90 is highly emphasized especially in cancer cells. Thus, much efforts for discovery and development of Hsp90 inhibitor have been continued and a few Hsp90 inhibitors targeting the N-terminal ATP binding site are being tested in the clinical trials. There are no metabolic signature molecules that can be used to evaluate the effect of Hsp90 inhibition. We previously found a potential C-domain binder named PPC1 that is a synthetic small molecule. Here we report the metabolomics study to find signature metabolites upon treatment of PPC1 compound in lung cancer cell line, A549 and discuss the potentiality of metabolomic approach for evaluation of hit compounds.
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참고문헌 (10)
참고문헌 신청
Hee-Eun Kim / 2012 / Metabolic classification of herb plants by NMR-based metabolomics / Journal of the Korean Magnetic Resonance Society 16 (2) : 91 ~ 102
McDowell, C. / 2009 / / International Journal of Biological Macromolecules 45 : 310 ~ 314
Park, SJ. / 2011 / / J Mol Biol 411 (1) : 158 ~ 173
Park, SJ. / 2011 / / Nature Structural & Molecular Biology 18 (5) : 537 ~ 541
Richter, K. / 2001 / / J. Cell Physiol 188 : 281 ~ 290
McDowell, C. / 2009 / / International Journal of Biological Macromolecules 45 : 310 ~ 314
Park, SJ. / 2011 / / J Mol Biol 411 (1) : 158 ~ 173
Park, SJ. / 2011 / / Nature Structural & Molecular Biology 18 (5) : 537 ~ 541
Richter, K. / 2001 / / J. Cell Physiol 188 : 281 ~ 290
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