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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 57 - 66 (10page)
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Programmed cell death systems are important for an active type of cell deaths. Among them, a type of programmed cell death, autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Thus, in the area of cancer, over the time frame form around the 1940s to date, of the 155 small molecules, 73% are other than “synthetic”, with 47% actually being either “natural products”or “directly derived therefrom”. Autophagy has multiple physiological functions in multicellular organisms, including protein degradation and organelle turnover. Genes and proteins that constitute the basic machinery of the autophagic process were first identified in the yeast system and some of their mammalian orthologues have been characterized as well. Numerous oncogenes, including Akt1, Bcl-2, NF1,PDPK1, class I PI3K, PTEN, and Ras and oncosuppressors,inculuding Bec-1, Bif-1, DAPK-1, p53 and UVRAG suppress or promote the autophagy pathway. Regulation of autophagy in tumors is governed by similar principles of the normal cells, only in a much more complicated manner,given the frequently observed abnormal PI3K activation in cancer and the multitude of interactions between the PI3K/AKT/mTOR pathway and other cell signaling cascades,often also deregulated in tumor cells. Autophagy induction by some anticancer agents underlines the potential utility of its induction as a new cancer treatment modality of development for natural medicines.
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참고문헌 (24)
참고문헌 신청
Abedin MJ / 2007 / Autophagy delays apoototic death in breast cancer cells following DNA damage / Cell Death Differ 14 : 500 ~ 510
Abida WM / 2008 / p53-Dependent and p53-independent activation of autophagy by ARF / Cancer Res 68 : 352 ~ 357
Ahlberg J / 1987 / Charac terization of the proteolytic compartment in rat hepatocyte nodules / Virchows Arch B Cell Pathol Incl Mol Pathol 53 : 79 ~ 88
Allgayer H / 2008 / An introduction to molecular targeted therapy of cancer / Advances in medical sciences 53 : 130 ~ 138
Apel A / 2008 / Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy / Cancer Res 68 : 1485 ~ 1494
Abida WM / 2008 / p53-Dependent and p53-independent activation of autophagy by ARF / Cancer Res 68 : 352 ~ 357
Ahlberg J / 1987 / Charac terization of the proteolytic compartment in rat hepatocyte nodules / Virchows Arch B Cell Pathol Incl Mol Pathol 53 : 79 ~ 88
Allgayer H / 2008 / An introduction to molecular targeted therapy of cancer / Advances in medical sciences 53 : 130 ~ 138
Apel A / 2008 / Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy / Cancer Res 68 : 1485 ~ 1494
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