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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 183 - 193 (11page)
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Hydrogen peroxide (H2O2) functions as a ubiquitous intracellular messenger besides as an oxidative stress molecule. This dual role is based on the distinct cellular responses against different concentrations of H2O2. Previously, we demonstrated that both low (> 1 mM) and high (4-10 mM) doses of exogenous H2O2 induce filamentous growth with distinct cell morphology and growth rate in Candida albicans, suggesting the different transcription response. In this study, we revealed that the sub-toxic and toxic levels of H2O2 indeed induced pseudohyphae, but not true hyphae. Supporting this, several hyphae-specific genes that are expressed in true hyphae induced by serum were not detected in either sub-toxic or toxic H2O2 condition. A DNA microarray analysis was conducted to reveal the transcription profiles in cells treated with sub-toxic and toxic conditions of H2O2. Under the sub-toxic condition, a small number of genes involved in cell proliferation and metabolism were up-regulated, whereas a large number of genes were up-regulated in the toxic condition where the genes required for growth and proliferation were selectively restricted. For pseudohyphal induction by sub-toxic H2O2, Cek1 MAPK activating the transcription factor Cph1 was shown to be important. The absence of expression of several hyphae-specific genes known to be downstream targets of Cph1-signaling pathway for true hyphae formation suggests that the Cek1-mediated signaling pathway is not solely responsible for pseudohyphal formation by sub-toxic H2O2 and, but instead, complex networking pathway may exists by the activation of different regulators.
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참고문헌 (63)
참고문헌 신청
Kadosh, D. / 2001 / Rfg1, a protein related to the Saccharomyces cerevisiae hypoxic regulator Rox1, controls filamentous growth and virulence in Candida albicans / Mol. Cell. Biol 21:2496~2505
Kunze, D. / 2007 / Odds FC, Hube B. Multiple functions of DOA1 in Candida albicans / Microbiology 153:1026~1041
Lane, S. / 2001 / array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans / J. Biol. Chem 276:48988~48996
Leberer, E. / 1996 / Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans / Proc. Natl. Acad. Sci 93:13217~13222
Leng, P. / 2001 / Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein / J. Bacteriol 183:4090~4093
Kunze, D. / 2007 / Odds FC, Hube B. Multiple functions of DOA1 in Candida albicans / Microbiology 153:1026~1041
Lane, S. / 2001 / array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans / J. Biol. Chem 276:48988~48996
Leberer, E. / 1996 / Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans / Proc. Natl. Acad. Sci 93:13217~13222
Leng, P. / 2001 / Efg1, a morphogenetic regulator in Candida albicans, is a sequence-specific DNA binding protein / J. Bacteriol 183:4090~4093
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