지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 203 - 210 (8page)
이용수
초록· 키워드
오류제보하기
1,2-Dibromoethane and glycidol are well known genotoxic carcinogens, which have been widely used in industry. To identify a specific biomarker for these car-cinogens in cells, the cellular proteome of L5178Y mouse lymphoma cells treated with these compounds was ana-lyzed by 2-dimen-sional gel electrophoresis (2-DE) and MALDI-TOF mass spectrometry (MS). Of 50 protein spots showing a greater than 1.5-fold increase or decrease in intensity compared to control cells on a 2-D gel, we fo-cused on the candidate biomarker moesin. Western analysis using monoclonal rabbit anti-moesin confirmed the identity of the protein and its increased level of expression upon exposure to the carcinogenic compounds. Moesin expression also increased in cells treated with six additional genotoxic carcinogens, verifying that moesin could serve as a biomarker to monitor phenotypic change upon exposure to genotoxic carcinogens in L5178Y mouse lymphoma cells.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bandara, L. R. / 2002 / Toxicoproteomics--a newpreclinical tool. Drug Discov / Today 7 : 411 ~ 418
Biswas, G. / 2008 / Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling / Proc. Natl. Acad. Sci 105 : 186 ~ 191
Charafe-Jauffret, E. / 2007 / Moesin expression is a marker of basal breast carcinomas / Int. J. Cancer 121 : 1779 ~ 1785
Cho, S.Y / 2005 / Efficient prefractionation of low-abundance proteins in human plasma and construction of a two-dimensional map / PROTEOMICS 5 : 3386 ~ 3396
Clark, L. S. / 1998 / Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells / Mutagenesis 13
Biswas, G. / 2008 / Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling / Proc. Natl. Acad. Sci 105 : 186 ~ 191
Charafe-Jauffret, E. / 2007 / Moesin expression is a marker of basal breast carcinomas / Int. J. Cancer 121 : 1779 ~ 1785
Cho, S.Y / 2005 / Efficient prefractionation of low-abundance proteins in human plasma and construction of a two-dimensional map / PROTEOMICS 5 : 3386 ~ 3396
Clark, L. S. / 1998 / Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells / Mutagenesis 13
이 논문의 저자 정보
최근 본 자료
댓글(0)
0