지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 163 - 171 (9page)
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초록· 키워드
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The DJ-1 superfamily (DJ-1/ThiJ/PfpI superfamily) is distributed across all three kingdoms of life. These pro-teins are involved in a highly diverse range of cellular functions, including chaperone and protease activity. DJ-1 proteins usually form dimers or hexamers in vivo and show at least four different binding orientations via distinct interface patches. Abnormal oligomerization of human DJ-1 is related to neurodegenerative disorders including Parkinson’s disease, suggesting important functional roles of quaternary structures. However, the quaternary structures of the DJ-1 superfamily have not been extensively studied. Here, we focus on the diverse oligomerization modes among the DJ-1 superfamily proteins and investigate the functional roles of quaternary structures both computationally and experimentally. The oligomerization modes are classified into 4 types (DJ-1, YhbO, Hsp, and YDR types) depending on the distinct interface patches (I-IV) upon dimerization. A unique, rotated interface via patch I is reported, which may potentially be related to higher order oligomerization. In general, the groups based on sequence similarity are consistent with the quaternary structural classes, but their biochemical functions cannot be directly inferred using sequence information alone. The observed phyletic pattern suggests the dynamic nature of quaternary structures in the course of evolution. The amino acid residues at the interfaces tend to show lower mutation rates than those of non-interfacial surfaces.
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참고문헌 (24)
참고문헌 신청
Abdallah, J. / 2006 / Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli / Protein Expr. Purif 47 : 455 ~ 460
Abdallah, J. / 2007 / YhbO protects cells against multiple stresses / J. Bacteriol 189 : 9140 ~ 9144
Bandyopadhyay, S. / 2004 / Evolutionary and functional relationships within the DJ1 superfamily / BMC Evol. Biol 4 (6)
Bonifati, V. / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299 : 256 ~ 259
Brunger, A. T. / 1998 / Crystallography & NMR system: a new software suite for macromolecular structure determination / Acta Crystallogr. D Biol. Crystallogr 54 : 905 ~ 9
Abdallah, J. / 2007 / YhbO protects cells against multiple stresses / J. Bacteriol 189 : 9140 ~ 9144
Bandyopadhyay, S. / 2004 / Evolutionary and functional relationships within the DJ1 superfamily / BMC Evol. Biol 4 (6)
Bonifati, V. / 2003 / Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism / Science 299 : 256 ~ 259
Brunger, A. T. / 1998 / Crystallography & NMR system: a new software suite for macromolecular structure determination / Acta Crystallogr. D Biol. Crystallogr 54 : 905 ~ 9
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