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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 282 - 287 (6page)
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초록· 키워드
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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a homo-trimeric cytotoxic ligand. Several studies have demonstrated that incorporation of artificial trimerization motifs into the TRAIL protein leads to the enhancement of biological activity. Here, we show that linkage of the isoleucine zipper hexamerization motif to the N-terminus of TRAIL, referred as ILz(6):TRAIL, leads to multimerization of its trimeric form, which has higher cytotoxic activity compared to its native state. Size exclusion chromatography of ILz(6):TRAIL revealed possible existence of various forms such as trimeric, hexameric, and multimeric (possibly containing one-, two-, and multi-units of trimeric TRAIL, respectively). Increased number of multimerized ILz(6):TRAIL units corresponded with enhanced cytotoxic activity. Further, a high degree of ILz(6):TRAIL multimerization triggered rapid signaling events such as activation of caspases, tBid generation, and chromatin condensation. Taken together, these results indicate that multimerization of TRAIL significantly enhances its cytotoxic activity.
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참고문헌 (16)
참고문헌 신청
Wiley SR / 1995 / Identification, characterization of a new member of the TNF family that induces apoptosis / Immunity 3:673~682
Pitti RM / 1996 / Induction of apoptosis by Apo-2ligand, a new member of the tumor necrosis factor cytokine family / J Biol Chem 271:12687~12690
Chaudhary PM / 1997 / Death receptor 5, a new member of the TNFR family, , DR4 induce FADD-dependent apoptosis, activate the NF-kappaB pathway / Immunity 7:821~830
Schneider P / 1997 / TRAIL receptors 1(DR4), 2(DR5)signal FADD-dependent apoptosis, activate NF-kappaB / Immunity 7:831~836
Sheridan JP / 1997 / Control of TRAIL-induced apoptosis by a family of signaling, decoy receptors / Science 277:818~821
Pitti RM / 1996 / Induction of apoptosis by Apo-2ligand, a new member of the tumor necrosis factor cytokine family / J Biol Chem 271:12687~12690
Chaudhary PM / 1997 / Death receptor 5, a new member of the TNFR family, , DR4 induce FADD-dependent apoptosis, activate the NF-kappaB pathway / Immunity 7:821~830
Schneider P / 1997 / TRAIL receptors 1(DR4), 2(DR5)signal FADD-dependent apoptosis, activate NF-kappaB / Immunity 7:831~836
Sheridan JP / 1997 / Control of TRAIL-induced apoptosis by a family of signaling, decoy receptors / Science 277:818~821
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