지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 336 - 341 (6page)
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초록· 키워드
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Endothelial cell protein C receptor (EPCR) plays important roles in blood coagulation and inflammation. EPCR activity ismarkedly changed by ectodomain cleavage and release as thesoluble EPCR. EPCR can be shed from the cell surface, whichis mediated by tumor necrosis factor-α converting enzyme(TACE). Oroxylin A (OroA), a major component of Scutellariabaicalensis Georgi, is known to exhibit anti-angiogenic, antiinflammation,and anti-invasive activities. However, little isknown about the effects of OroA on EPCR shedding. Datashowed that OroA induced potent inhibition of phorbol-12-myristate 13-acetate (PMA), tumor necrosis factor (TNF)-α,interleukin (IL)-1β and on cecal ligation and puncture (CLP)-induced EPCR shedding through suppression of TACE expressionand activity. In addition, treatment with OroA resulted inreduced PMA-stimulated phosphorylation of p38, extracellularregulated kinases (ERK) 1/2, and c-Jun N-terminal kinase (JNK).
These results demonstrate the potential of OroA as ananti-sEPCR shedding reagent against PMA and CLP-mediated EPCR shedding.
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참고문헌 (22)
참고문헌 신청
Borgel, D. / 2007 / A comparative study of the protein C pathway in septic and nonseptic patients with organ failure / Am. J. Respir. Crit. Care Med 176 : 878 ~ 885
Esmon, C. T. / 2004 / Structure and functions of the endothelial cell protein C receptor / Crit. Care. Med 32 : 298 ~ 301
Fukudome, K. / 1994 / Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor / J. Biol. Chem 269 : 26486 ~ 26491
Fukudome, K. / 1996 / The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor / J. Biol. Chem 271 : 17491 ~ 17498
Ghosh, S. / 2007 / Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium / J. Biol. Chem 282 : 11849 ~ 11857
Esmon, C. T. / 2004 / Structure and functions of the endothelial cell protein C receptor / Crit. Care. Med 32 : 298 ~ 301
Fukudome, K. / 1994 / Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor / J. Biol. Chem 269 : 26486 ~ 26491
Fukudome, K. / 1996 / The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor / J. Biol. Chem 271 : 17491 ~ 17498
Ghosh, S. / 2007 / Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium / J. Biol. Chem 282 : 11849 ~ 11857
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