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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 324 - 329 (6page)
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초록· 키워드
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Regulators of G-protein signaling (RGS) proteins regulatecertain G-protein-coupled receptor (GPCR)-mediated signalingpathways. The GABAB receptor (GABABR) is a GPCR that playsa role in the stress response. Previous studies indicate thatacute immobilization stress (AIS) decreases RGS4 in theprefrontal cortex (PFC) and hypothalamus (HY) and suggest thepossibility of a signal complex composed of RGS4 andGABABR. Therefore, in the present study, we tested whetherRGS4 associates with GABABR in these brain regions. Wefound the co-localization of RGS4 and GABABR subtypes inthe PFC and HY using double immunohistochemistry andconfirmed a direct association between GABAB2R and RGS4proteins using co-immunoprecipitation. Furthermore, wefound that AIS decreased the amount of RGS4 bound toGABAB2R and the number of double-positive cells. Theseresults indicate that GABABR forms a signal complex withRGS4 and suggests that RGS4 is a regulator of GABABR.
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참고문헌 (22)
참고문헌 신청
Calogero, A. E. / 1988 / Interaction between GABAergic neurotransmission and rat hypothalamic corticotropin-releasing hormone secretion in vitro / Brain Res 463 : 28 ~ 36
Cavalli, A. / 2000 / The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha / J. B
De Vries, L. / 2000 / The regulator of G protein signaling family / Annu. Rev. Pharmacol. Toxicol 40 : 235 ~ 271
Dedovic, K. / 2009 / The brain and the stress axis: The neural correlates of cortisol regulation in response to stress / NeuroImage 47 : 864 ~ 871
Ding, J. / 2006 / RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion / Nat. Neurosci 9 : 832 ~ 842
Cavalli, A. / 2000 / The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha / J. B
De Vries, L. / 2000 / The regulator of G protein signaling family / Annu. Rev. Pharmacol. Toxicol 40 : 235 ~ 271
Dedovic, K. / 2009 / The brain and the stress axis: The neural correlates of cortisol regulation in response to stress / NeuroImage 47 : 864 ~ 871
Ding, J. / 2006 / RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion / Nat. Neurosci 9 : 832 ~ 842
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