지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 47 - 52 (6page)
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Intestinal epithelial cell (IEC) apoptosis induced by hypoxia compromise intestinal epithelium barrier function. Both Akt and Hsp90 have cytoprotective function. However, the specific role of Akt and Hsp90β in IEC apoptosis induced by hypoxia has not been explored. We confirmed that hypoxia-induced apoptosis was reduced by Hsp90β overexpression but enhanced by decreasing Hsp90β expression. Hsp90β overexpression enhanced BAD phosphorylation and thus reduced mitochondrial release of cytochrome C. Reducing Hsp90β expression had opposite effects. The protective effect of Hsp90β against apoptosis was negated by LY294002, an Akt inhibitor. Further study showed that Akt phosphorylation was enhanced by Hsp90β, which was not due to the activation of upstream PI3K and PDK1 but because of stabilization of pAkt via direct interaction between Hsp90β and pAkt. These results demonstrate that Hsp90β may play a significant role in protecting IECs from hypoxia-induced apoptosis via stabilizing pAkt to phosphorylate BAD and reduce cytochrome C release.
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참고문헌 (29)
참고문헌 신청
Hotchkiss, R. S. / 2003 / Role of apoptotic cell death in sepsis / Scand. Infect. Dis 35:585~592
Galea-Lauri, J. / 1996 / Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology / J. Immunol 157:4109~4118
Beere, H. M. / 2004 / The stress of ding': the role of heat shock proteins in the regulation of apoptosis / J. Cell Sci 117:2641~2651
Giustiniani, J. / 2009 / Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53 / Cell Signal 21:529~539
Zhang, K. R. / 2007 / Long-term aerobic exercise protects the heart against ischemia/ reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism / Apoptosis 12:1579~1588
Galea-Lauri, J. / 1996 / Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology / J. Immunol 157:4109~4118
Beere, H. M. / 2004 / The stress of ding': the role of heat shock proteins in the regulation of apoptosis / J. Cell Sci 117:2641~2651
Giustiniani, J. / 2009 / Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53 / Cell Signal 21:529~539
Zhang, K. R. / 2007 / Long-term aerobic exercise protects the heart against ischemia/ reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism / Apoptosis 12:1579~1588
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