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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 595 - 600 (6page)
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Pax 6, a member of the paired box (Pax) family, has been implicated in oncogenesis. However, its therapeutic potential has been never examined in breast cancer. To explore the role of Pax6 in breast cancer development, a lentivirus based short hairpin RNA (shRNA) delivery system was used to knockdown Pax6 expression in estrogen receptor (ER)-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells. Effect of Pax6silencing on breast cancer cell proliferation and tumorigenesis was analyzed. Pax6-RNAi-lentivirus infection remarkably downregulated the expression levels of Pax6 mRNA and protein in MCF-7 and MDA-MB-231 cells. Accordingly, the cell viability,DNA synthesis, and colony formation were strongly suppressed,and the tumorigenesis in xenograft nude mice was significantly inhibited. Moreover, tumor cells were arrested at G0/G1 phase after Pax6 was knocked down. Pax6 facilitates important regulatory roles in breast cancer cell proliferation and tumor progression, and could serve as a diagnostic marker for clinical investigation. [BMB reports 2011; 44(9): 595-600]
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참고문헌 (23)
참고문헌 신청
Anandappa, S. Y / 2000 / Variant estrogen receptor alpha mRNAs in human breast cancer specimens / Int. J. Cancer 88 : 209 ~ 216
Dohrmann, C / 2000 / Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas / Mech. Dev 92 : 47 ~ 54
Hellwinkel, O. J / 2008 / Methylation of the TPEF- and PAX6-promoters is increased in early bladder cancer and in normal mucosa adjacent to pTa tumours / BJU Int 101 : 753 ~
Hill, R. E / 1992 / Mouse small eye results from mutations in a paired-like homeobox-containing gene / Nature 355 : 750 ~
Kashiwagi, Y / 2010 / Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines / Mol. Vis 16 : 970 ~ 982
Dohrmann, C / 2000 / Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas / Mech. Dev 92 : 47 ~ 54
Hellwinkel, O. J / 2008 / Methylation of the TPEF- and PAX6-promoters is increased in early bladder cancer and in normal mucosa adjacent to pTa tumours / BJU Int 101 : 753 ~
Hill, R. E / 1992 / Mouse small eye results from mutations in a paired-like homeobox-containing gene / Nature 355 : 750 ~
Kashiwagi, Y / 2010 / Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines / Mol. Vis 16 : 970 ~ 982
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