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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 462 - 467 (6page)
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초록· 키워드
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Up-regulation of selected matrix metalloproteinases (MMPs)such as MMP-9 contributes to inflammatory processes during the development of various skin diseases, such as atopic dermatitis. In this study, we examined the effect of a cell-permeable superoxide dismutase (Tat-SOD) on TNF-α-induced MMP-9 expression in human keratinocyte cells (HaCaT).
When Tat-SOD was added to the culture medium of HaCaT cells, it rapidly entered the cells in dose- and time-dependent manners. Tat-SOD decreased TNF-α-induced reactive oxygen species (ROS) generation. Tat-SOD also inhibited TNF-α-induced NF-κB DNA binding activity. Treatment of HaCaT cells with Tat-SOD significantly inhibited TNF-α-induced mRNA and protein expression of MMP-9, as measured by RT-PCR and Western blot analysis. In addition, Tat-SOD suppressed TNF-α-induced gelatinolytic activity of MMP-9. Taken together,our results indicate that Tat-SOD can suppress TNF-α-induced MMP-9 expression via ROS-NF-κB-dependent mechanisms in keratinocytes, and therefore can be used as an immunomodulatory agent against inflammatory skin diseases related to oxidative stress.
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참고문헌 (22)
참고문헌 신청
Bahar-Shany, K / 2010 / Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D / J. Cell. Physiol 222 : 729 ~ 737
Bickers, D. R / 2006 / Oxidative stress in the pathogenesis of skin disease / J. Invest. Dermatol 126 : 2565 ~ 2575
Brenneisen, P / 2001 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973 : 31 ~ 43
Deane, J. A / 2009 / Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging / Expert. Rev. Mol. Med 11 : e25 ~
Devillers, A. C / 2007 / Elevated levels of plasma matrix metalloproteinase- 9 in patients with atopic dermatitis: a pilot study / Clin. Exp. Dermatol 32 : 311 ~ 313
Bickers, D. R / 2006 / Oxidative stress in the pathogenesis of skin disease / J. Invest. Dermatol 126 : 2565 ~ 2575
Brenneisen, P / 2001 / Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events / Ann. N. Y. Acad. Sci 973 : 31 ~ 43
Deane, J. A / 2009 / Molecular mechanisms of leukocyte trafficking in T-cell-mediated skin inflammation: insights from intravital imaging / Expert. Rev. Mol. Med 11 : e25 ~
Devillers, A. C / 2007 / Elevated levels of plasma matrix metalloproteinase- 9 in patients with atopic dermatitis: a pilot study / Clin. Exp. Dermatol 32 : 311 ~ 313
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