지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 250 - 255 (6page)
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초록· 키워드
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In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specific (TS) genes to classify TS expression in humans.
Using TS domains and transcriptional factor binding sites (TFBSs), sequence characteristics were used as indices of expressed tissues in a Random Forest algorithm by scoring exclusive patterns considering the biological intuition; TFBSs regulate gene expression, and the domains reflect the functional specificity of a TS gene. Our proposed approach displayed better performance than previous attempts and was validated using computational and experimental methods. [BMB reports 2011; 44(4): 250-255]
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Andersson, T / 2009 / Tissue-specific increases in 11beta-hydroxysteroid dehydrogenase type 1 in normal weight postmenopausal women / PLoS One 4 : e8475 ~
Bossi, A / 2009 / Tissue specificity and the human protein interaction network / Mol. Syst. Biol 5 : 260 ~
Breiman, L / 2001 / Random forests / Machine Learning 45 : 5 ~ 32
Butte, A. J / 2001 / Further defining housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues / Physiol. Genomics 7 : 95 ~ 96
Cohen-Gihon, I / 2005 / Modular genes with metazoan-specific domains have increased tissue specificity / Trends Genet 21 : 210 ~ 213
Bossi, A / 2009 / Tissue specificity and the human protein interaction network / Mol. Syst. Biol 5 : 260 ~
Breiman, L / 2001 / Random forests / Machine Learning 45 : 5 ~ 32
Butte, A. J / 2001 / Further defining housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues / Physiol. Genomics 7 : 95 ~ 96
Cohen-Gihon, I / 2005 / Modular genes with metazoan-specific domains have increased tissue specificity / Trends Genet 21 : 210 ~ 213
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