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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 267 - 272 (6page)
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ZAS3 is a large zinc finger transcription repressor that binds the κB-motif via two signature domains of ZASN and ZASC. A loss-of-function study showed that lack of ZAS3 protein induced accelerated cell proliferation and tumorigenesis. Conversely,gain-of-function studies showed that ZAS3 repressed NFκB-activated transcription by competing with NFκB for the κB-motif. Based on these observations, we hypothesize that ZAS3 promotes apoptosis by interrupting anti-apoptotic activity of NFκB. Here, we present evidence that upon TNFα stimulation,ZAS3 inhibits NFκB-mediated cell survival and promotes caspase-mediated apoptosis. The inhibitory effect of ZAS3 on NFκB activity is mediated by neither direct association with NFκB nor disrupting nuclear localization of NFκB.
Instead, ZAS3 repressed the expression of two key anti-apoptotic genes of NFκB, TRAF1 and TRAF2, thereby sensitizing cells to TNFα-induced cell death. Taken together, our data suggest that ZAS3 is a tumor suppressor gene and therefore serves as a novel therapeutic target for developing anti-cancer drugs. [BMB reports 2011; 44(4): 267-272]
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참고문헌 (23)
참고문헌 신청
Aggarwal, B. B / 2000 / Tumour necrosis factors receptor associated signaling molecules and their role in activation of apoptosis, JNK and NF-κB / Ann. Rheum. Dis 59 (suppl
Allen, C. E / 2000 / Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells / Exp. Cell Res 260 : 346 ~ 356
Allen, C. E / 2002 / The κB transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection
Arsura, M / 2000 / Role of the IκB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells / Mol. Cell Biol 20 : 5381 ~ 5391
Baldwin, A. S. Jr / 2001 / Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB / J. Clin. Invest 107 : 241 ~ 246
Allen, C. E / 2000 / Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells / Exp. Cell Res 260 : 346 ~ 356
Allen, C. E / 2002 / The κB transcriptional enhancer motif and signal sequences of V(D)J recombination are targets for the zinc finger protein HIVEP3/KRC: a site selection
Arsura, M / 2000 / Role of the IκB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells / Mol. Cell Biol 20 : 5381 ~ 5391
Baldwin, A. S. Jr / 2001 / Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB / J. Clin. Invest 107 : 241 ~ 246
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