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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 655 - 661 (7page)
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초록· 키워드
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Polymer brush is a soft material unit tethered covalently on the surface of scaffolds. It can induce functional and structural modification of a substrate's properties. Such surface coating approach has attracted special attentions in the fields of stem cell biology, tissue engineering, and regenerative medicine due to facile fabrication, usability of various polymers, extracellular matrix (ECM)-like structural features, and in vivo stability. Here, we summarized polymer brush-based grafting approaches comparing self-assembled monolayer (SAM)-based coating method, in addition to physico-chemical characterization techniques for surfaces such as wettability, stiffness/ elasticity, roughness, and chemical composition that can affect cell adhesion, differentiation, and proliferation. We also reviewed recent advancements in cell biological applications of polymer brushes by focusing on stem cell differentiation and 3D supports/implants for tissue formation. Understanding cell behaviors on polymer brushes in the scale of nanometer length can contribute to systematic understandings of cellular responses at the interface of polymers and scaffolds and their simultaneous effects on cell behaviors for promising platform designs.
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참고문헌 (45)
참고문헌 신청
Krishnamoorthy M / 2014 / Surface-initiated polymer brushes in the biomedical field : applications in membrane science, biosensing cell culture regenerative medicine and antibacterial coatings / Chem Rev 114:10976~11026
Azzaroni O / 2012 / Polymer brushes here, there, and everywhere : Recent advances in their practical applications and emerging opportunities in multiple research fields / J Polym Sci A Polym Chem 50:3225~3258
Moroni L / 2014 / Polymer brush coatings regulating cell behavior : Passive interfaces turn into active / Acta Biomater 10:2367~2378
Raynor JE / 2009 / Polymer brushes and self-assembled monolayers: versatile platforms to control cell adhesion to biomaterials / Biointerphases 4:FA3~FA16
Von der Mark K / 2010 / Nanoscale engineering of biomimetic surfaces : cues from the extracellular matrix / Cell Tissue Res 339:131~153
Azzaroni O / 2012 / Polymer brushes here, there, and everywhere : Recent advances in their practical applications and emerging opportunities in multiple research fields / J Polym Sci A Polym Chem 50:3225~3258
Moroni L / 2014 / Polymer brush coatings regulating cell behavior : Passive interfaces turn into active / Acta Biomater 10:2367~2378
Raynor JE / 2009 / Polymer brushes and self-assembled monolayers: versatile platforms to control cell adhesion to biomaterials / Biointerphases 4:FA3~FA16
Von der Mark K / 2010 / Nanoscale engineering of biomimetic surfaces : cues from the extracellular matrix / Cell Tissue Res 339:131~153
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