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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 496 - 508 (13page)
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초록· 키워드
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Fas-associated protein with death domain (FADD), an adaptor that bridges death receptor signaling to the caspase cascade, is indispensible for the induction of extrinsic apoptotic cell death.
Interest in the non-apoptotic function of FADD has greatly increased due to evidence that FADD-deficient mice or dominant-negative FADD transgenic mice result in embryonic lethality and an immune defect without showing apoptotic features. Numerous studies have suggested that FADD regulates cell cycle progression, proliferation, and autophagy, affecting these phenomena. Recently, programmed necrosis, also called necroptosis, was shown to be a key mechanism that induces embryonic lethality and an immune defect. Supporting these findings, FADD was shown to be involved in various necroptosis models. In this review, we summarize the mechanism of extrinsic apoptosis and necroptosis, and discuss the in vivo and in vitro roles of FADD in necroptosis induced by various stimuli.
[BMB Reports 2012; 45(9): 496-508]
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참고문헌 (22)
참고문헌 신청
Alappat, E. C. / 2003 / Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site / J. Biol. Chem. 278 : 41585 ~ 41588
Alappat, E. C. / 2005 / Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities / Mol. Cell 19 : 321 ~ 332
Bhojani, M. S. / 2005 / Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer / Cell Cycle. 4 : 1478 ~ 1481
Bonnet, M. C. / 2011 / The adaptor protein fadd protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation / Immunity 35 : 572 ~ 582
Chen, G. / 2005 / Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas / Proc. Natl. Acad. Sci. U.S.A. 102 : 125
Alappat, E. C. / 2005 / Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities / Mol. Cell 19 : 321 ~ 332
Bhojani, M. S. / 2005 / Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer / Cell Cycle. 4 : 1478 ~ 1481
Bonnet, M. C. / 2011 / The adaptor protein fadd protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation / Immunity 35 : 572 ~ 582
Chen, G. / 2005 / Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas / Proc. Natl. Acad. Sci. U.S.A. 102 : 125
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