지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 22 - 27 (6page)
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초록· 키워드
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A series of elastin-like proteins, SKGPG[V(VKG)3VKVPG]n-(ELP1-90)WP (n = 1, 2, 3, and 4), were biosynthesized based on the hydrophobic and lysine linkage domains of tropoelastin. The formation of self-assembled hydrophobic aggregates was monitored in order to determine the influence of cationic segments on phase transition properties as well as the sensitivity to changes in salt and pH. The thermal transition profiles of the proteins fused with only one or two cationic blocks (n = 1 or 2) were similar to that of the counterpart ELP1-90. In contrast,diblock proteins that contain 3 and 4 cationic blocks displayed a triphasic profile and no transition, respectively. Upon increasing the salt concentration and pH, a stimulus-induced phase transition from a soluble conformation to an insoluble aggregate was observed. The effects of cationic segments on the stimuli sensitivity of cationic bimodal ELPs were interpreted in terms of their structural and molecular characteristics.
[BMB reports 2011; 44(1): 22-27]
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참고문헌 (22)
참고문헌 신청
Bae, Y / 2007 / Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin / J. Control.
Bashir, M. M / 1989 / Characterization of the complete human elastin gene. Delineation of unusual features in the 5-flanking region / J. Biol. Chem 264 : 8887 ~ 8891
Brown-Augsburgert, P / 1995 / Identification of an elastin cross-linking domain that joins three peptide chains / J. Biol. Chem 270 : 17778 ~ 17783
Chen, T. H / 2008 / Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery / Pharm. Res 25 : 683 ~ 691
Chilkoti, A / 2006 / Stimulus responsive elastin biopolymers: applications in medicine and biotechnology / Curr. Opin. Chem. Biol 10 : 652 ~ 657
Bashir, M. M / 1989 / Characterization of the complete human elastin gene. Delineation of unusual features in the 5-flanking region / J. Biol. Chem 264 : 8887 ~ 8891
Brown-Augsburgert, P / 1995 / Identification of an elastin cross-linking domain that joins three peptide chains / J. Biol. Chem 270 : 17778 ~ 17783
Chen, T. H / 2008 / Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery / Pharm. Res 25 : 683 ~ 691
Chilkoti, A / 2006 / Stimulus responsive elastin biopolymers: applications in medicine and biotechnology / Curr. Opin. Chem. Biol 10 : 652 ~ 657
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