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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 146 - 149 (4page)
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초록· 키워드
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Exendin-4 (Ex-4), a peptide secreted from the salivary glands of the Gila monster lizard, can increase pancreatic β-cell growth and insulin secretion by activating glucagon-like peptide-1receptor. In this study, we expressed a fusion protein consisting of exendin-4 and the human immunoglobulin heavy chain (Ex-4/IgG-Fc) in E. coli and explored its potential therapeutic use for the treatment of insulin-resistant type 2 diabetes. Here,we show that the Ex-4/IgG-Fc fusion protein induces expression of insulin receptor substrate-2 in rat insulinoma INS-1cells. Our findings therefore suggest that Ex-4/IgG-Fc overexpressed in E. coli could be used as a potential, long-acting glucagon-like peptide-1 mimetic.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Deacon, C. F. / 1995 / Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
Dong-Myung Kim / 2009 / Fc fusion to Glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human
Eng, J. / 1992 / Isolation and characterization of exendin- 4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed ac
Giannoukakis, N. / 2003 / Exenatide. Amylin/Eli Lilly / Curr. Opin. Investig. Drugs. 4 : 459 ~ 465
Huang, Y. S. / 2008 / Preparation and characterization of a novel exendin-4 human serum albumin fusion protein expressed in Pichia pastoris / J. Pept. Sci. 14 : 588 ~ 595
Dong-Myung Kim / 2009 / Fc fusion to Glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human
Eng, J. / 1992 / Isolation and characterization of exendin- 4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed ac
Giannoukakis, N. / 2003 / Exenatide. Amylin/Eli Lilly / Curr. Opin. Investig. Drugs. 4 : 459 ~ 465
Huang, Y. S. / 2008 / Preparation and characterization of a novel exendin-4 human serum albumin fusion protein expressed in Pichia pastoris / J. Pept. Sci. 14 : 588 ~ 595
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