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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 524 - 529 (6page)
이용수
이 논문의 연구 히스토리 (2)
2014
The identification of MafK as a novel target in NF-κB signaling : :Prunella vulgaris var. lilacina modulates inflammation by suppression of MafK expression
황유진
생명공
2014.01
학위논문
Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells
황유진
,
송재환
,
김행란
외 1명
BMB Reports
2014.01
학술저널
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초록· 키워드
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Oxidative stress and inflammation are common to manypathological conditions. Defense mechanisms protect cellsfrom oxidative stress, but can become over-activated followinginjury and inflammation. NF-κB and Nrf2 transcription factorsregulate proinflammatory and antioxidant gene expression,respectively. Studies have shown that many natural dietarycompounds regulate NF-κB and Nrf2, preventing inflammationand oxidative stress. Here, we report major compounds ofPrunella vulgaris var. lilacina such as rosmarinic acid,oleanolic acid, ursolic acid and caffeic acid as a potentialtherapeutic for oxidative stress and inflammation. The majorcompounds exhibited high anti-inflammatory activity, inhibitingNO, PGE2 production, NF-κB expression and activating Nrf2expression. In addition, we examined the effect of majorcompounds on MafK expression. Among the compounds,oleanolic acid significantly decreased MafK expression andMafK-mediated p65 acetylation. These findings suggest thatoleanolic acid as NF-κB inhibitors can potentially be used intherapeutic applications for the treatment of oxidative stressnduced diseases.
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참고문헌 (33)
참고문헌 신청
Chen, X. L. / 2004 / Induction of Cytoprotective Genes through Nrf2/Antioxidant Response Element Pathway: A New Therapeutic Approach for the Treatment of Inflammatory Diseases / Curr. Pharm. Des 10:879~891
Thimmulappa, R. K. / 2006 / Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis / J. Clin. Invest 116:984~995
Tak, P. P. / 2001 / NF-κB: a key role in inflammatory diseases / J. Clin. Invest 107:7~11
Pikarsky, E. / 2004 / NF-κB functions as a tumour promoter in inflammation-associated cancer / Nature 431:461~466
Balogun, E. / 2003 / Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element / Biochem. J 371:887~895
Thimmulappa, R. K. / 2006 / Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis / J. Clin. Invest 116:984~995
Tak, P. P. / 2001 / NF-κB: a key role in inflammatory diseases / J. Clin. Invest 107:7~11
Pikarsky, E. / 2004 / NF-κB functions as a tumour promoter in inflammation-associated cancer / Nature 431:461~466
Balogun, E. / 2003 / Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element / Biochem. J 371:887~895
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