지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 506 - 511 (6page)
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초록· 키워드
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We investigated the effects of high calorie and low caloriediets on skeletal integrity, and whether β-adrenergic blockade(BB) attenuates bone loss induced by dietary calorie alteration.
Male 6-week-old C57BL/6 mice were assigned to either anad-lib fed control diet (CON), a high calorie diet (HIGH), or alow calorie diet (LOW) group. In each diet group, mice weretreated with either vehicle (VEH) or propranolol, a β-adrenergicantagonist. Over 12-weeks, β-blockade mitigated bodyweight and fat mass increases induced by the high calorie diet.
Femoral trabecular bone mineral density and the expressionlevels of osteogenic marker genes in bone marrow cells werereduced in HIGHVEH and LOWVEH mice, and BB significantlyattenuated this decline only in HIGH mice. In summary,the magnitude of bone loss induced by low calorie diet wasgreater than that caused by high calorie diet in growing mice,and β-blockade mitigated high calorie diet-induced bone loss.
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참고문헌 (20)
참고문헌 신청
Baek, K. / 2009 / Beta-adrenergic blockade and leptin replacement effectively mitigate disuse bone loss / J. Bone Miner. Res 24 : 792 ~ 799
Baek, K. / 2012 / Blocking beta-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restric
Banu, M. J. / 1999 / Analysis of the effects of growth hormone, voluntary exercise, and food restriction on diaphyseal bone in female F344 rats / Bone 25 : 469 ~ 480
Bjurholm, A. / 1991 / Neuroendocrine peptides in bone / Int. Orthop 15 : 325 ~ 329
Bonnet, N. / 2007 / Combined effects of exercise and propranolol on bone tissue in ovariectomized rats / J. Bone Miner. Res 22 : 578 ~ 588
Baek, K. / 2012 / Blocking beta-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restric
Banu, M. J. / 1999 / Analysis of the effects of growth hormone, voluntary exercise, and food restriction on diaphyseal bone in female F344 rats / Bone 25 : 469 ~ 480
Bjurholm, A. / 1991 / Neuroendocrine peptides in bone / Int. Orthop 15 : 325 ~ 329
Bonnet, N. / 2007 / Combined effects of exercise and propranolol on bone tissue in ovariectomized rats / J. Bone Miner. Res 22 : 578 ~ 588
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