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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 512 - 517 (6page)
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In this study, we showed that Mycobacterium abscessusMAB2560 induces the maturation of dendritic cells (DCs),which are representative antigen-presenting cells (APCs). M.
abscessus MAB2560 stimulate the production of pro-inflammatorycytokines [interleukin (IL)-6, tumor necrosis factor (TNF)-α,IL-1β, and IL-12p70] and reduce the endocytic capacity andmaturation of DCs. Using TLR4-/- DCs, we found that MAB2560mediated DC maturation via Toll-like receptor 4 (TLR4).
MAB2560 also activated the MAPK signaling pathway, whichwas essential for DC maturation. Furthermore, MAB2560-treated DCs induced the transformation of naïve T cells topolarized CD4+ and CD8+ T cells, which would be crucial forTh1 polarization of the immune response. Taken together, ourresults indicate that MAB2560 could potentially regulate thehost immune response to M. abscessus and may have criticalimplications for the manipulation of DC functions fordeveloping DC-based immunotherapy.
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참고문헌 (26)
참고문헌 신청
Ordway, D. / 2008 / Animal model of Mycobacterium abscessus lung infection / J. Leukoc. Biol 83:1502~1511
Vilcek, J. / 1986 / Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis / J. Clin. Immunol 6:146~151
Lee, J. S. / 2009 / Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein activates dendritic cells and induces a Th1 polarization / Infect. Immun 77:2979~2988
Lee, S. J. / 2014 / The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4 / BMB Rep 47:115~120
Noh, K. T. / 2012 / Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia / J. Biol. Chem 287:14226~14233
Vilcek, J. / 1986 / Defective gamma-interferon production in peripheral blood leukocytes of patients with acute tuberculosis / J. Clin. Immunol 6:146~151
Lee, J. S. / 2009 / Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein activates dendritic cells and induces a Th1 polarization / Infect. Immun 77:2979~2988
Lee, S. J. / 2014 / The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4 / BMB Rep 47:115~120
Noh, K. T. / 2012 / Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia / J. Biol. Chem 287:14226~14233
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