지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 507 - 512 (6page)
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초록· 키워드
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Invasion of trophoblasts into maternal uterine tissue is essential for establishing mature feto-maternal circulation. The trophoblast invasion associated with placentation is similar to tumor invasion. In this study, we investigated the role of KAI1, an anti-metastasis factor, at the maternal-fetal interface during placentation. Mouse embryos were obtained from gestational days 5.5 (E5.5) to E13.5. Immunohistochemical analysis revealed that KAI1 was expressed on decidual cells around the track made when a fertilized ovum invaded the endometrium, at days E5.5 and E7.5, and on trophoblast giant cells, along the central maternal artery of the placenta at E9.5. KAI1 in trophoblast giant cells was increased at E11.5, and then decreased at E13.5.
Furthermore, KAI1 was upregulated during the forskolinmediated trophoblastic differentiation of BeWo cells. Collectively,these results indicate that KAI1 is differentially expressed in decidual cells and trophoblasts at the maternal-fetal interface,suggesting that KAI1 prevents trophoblast invasion during placentation. [BMB Reports 2013; 46(10): 507-512]
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참고문헌 (22)
참고문헌 신청
Cross, J. C. / 2002 / Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta / Mol. Cell. Endocrinol 187 : 207 ~ 212
Delidaki, M. / 2011 / Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line / Mol. Cell. Endocrinol 332 : 213 ~ 220
Dong, J. T. / 1995 / KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11. 2 / Science 268 : 884 ~ 886
Gellersen, B. / 2007 / Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal- fetal interface: Regulation and functional implications / Am. J.
Goldman-Wohl, D. / 2002 / Regulation of trophoblast invasion: from normal implantation to preeclampsia / Mol. Cell. Endocrinol 187 : 233 ~ 238
Delidaki, M. / 2011 / Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line / Mol. Cell. Endocrinol 332 : 213 ~ 220
Dong, J. T. / 1995 / KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11. 2 / Science 268 : 884 ~ 886
Gellersen, B. / 2007 / Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal- fetal interface: Regulation and functional implications / Am. J.
Goldman-Wohl, D. / 2002 / Regulation of trophoblast invasion: from normal implantation to preeclampsia / Mol. Cell. Endocrinol 187 : 233 ~ 238
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