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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 201 - 206 (6page)
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Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane] is an isothiocyanate found in some cruciferous vegetables, especially broccoli. Sulforaphane has been shown to display anti-cancer properties against various cancer cell lines. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in cancer cell invasion.
In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9expression and cell invasion in MCF-7 cells. TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment. TPA substantially increased NF-κB and AP-1 DNA binding activity. Pre-treatment with sulforaphane inhibited TPA-stimulated NF-κB binding activity, but not AP-1binding activity. In addition, we found that sulforaphane suppressed NF-κB activation, by inhibiting phosphorylation of IκB in TPA-treated MCF-7 cells. In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-κB pathway in MCF-7 cells.
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참고문헌 (21)
참고문헌 신청
Chambers, A. F. / 1997 / Changing views of the role of matrix metalloproteinases in metastasis / J. Natl. Cancer Inst 89 : 1260 ~ 1270
Chen, X. L. / 2009 / Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells / Inflamm. Res 58 : 513 ~ 521
Chung, T. W. / 2004 / Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metasta
Crawford, H. C. / 1996 / Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells / Enzyme Protein 49 : 20 ~ 37
Friedel, G. / 2002 / Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases / Eur.
Chen, X. L. / 2009 / Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells / Inflamm. Res 58 : 513 ~ 521
Chung, T. W. / 2004 / Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metasta
Crawford, H. C. / 1996 / Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells / Enzyme Protein 49 : 20 ~ 37
Friedel, G. / 2002 / Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases / Eur.
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