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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 207 - 212 (6page)
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초록· 키워드
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The main purpose of this study is to examine the effect of caffeine on lipid accumulation in human hepatoma HepG2cells. Significant decreases in the accumulation of hepatic lipids, such as triglyceride (TG), and cholesterol were observed when HepG2 cells were treated with caffeine as indicated.
Caffeine decreased the mRNA level of lipogenesis-associated genes (SREBP1c, SREBP2, FAS, SCD1, HMGR and LDLR). In contrast, mRNA level of CD36, which is responsible for lipid uptake and catabolism, was increased. Next, the effect of caffeine on AMP-activated protein kinase (AMPK) signaling pathway was examined. Phosphorylation of AMPK and acetyl-CoA carboxylase were evidently increased when the cells were treated with caffeine as indicated for 24 h. These effects were all reversed in the presence of compound C, an AMPK inhibitor. In summary, these data indicate that caffeine effectively depleted TG and cholesterol levels by inhibition of lipogenesis and stimulation of lipolysis through modulating AMPK-SREBP signaling pathways.
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참고문헌 (23)
참고문헌 신청
/ 2007 / Department of Agriculture Agricultural Research Service: USDA. National Nutrient Database for Standard Reference
Ching, Y. P. / 1996 / Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA re
Duffey, K. J. / 2002 / Shifts in patterns and consumption of beverages between 1965 and 2002 / Obesity 15 : 2739 ~ 2747
Eberle, D. / 2004 / SREBP transcription factors: master regulators of lipid homeostasis / Biochimi 86 : 839 ~ 848
Hardie, D. G. / 1997 / Regulation of lipid metabolism by the AMP-activated protein kinase / Biochem. Soc. Trans 25 : 1229 ~ 1231
Ching, Y. P. / 1996 / Analysis of the specificity of the AMP-activated protein kinase by site-directed mutagenesis of bacterially expressed 3-hydroxy 3-methylglutaryl-CoA re
Duffey, K. J. / 2002 / Shifts in patterns and consumption of beverages between 1965 and 2002 / Obesity 15 : 2739 ~ 2747
Eberle, D. / 2004 / SREBP transcription factors: master regulators of lipid homeostasis / Biochimi 86 : 839 ~ 848
Hardie, D. G. / 1997 / Regulation of lipid metabolism by the AMP-activated protein kinase / Biochem. Soc. Trans 25 : 1229 ~ 1231
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