지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 195 - 200 (6page)
이용수
초록· 키워드
오류제보하기
To understand the corneal regeneration induced by bevacizumab,we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour and 4 days after injury. At 7 days after injury, basement membrane regeneration was observed by transmission electron microscope. Uneven and thin epithelial basement membrane, light density of hemidesmosomes,and edematous collagen fibril bundles are shown in the alkali-burned cornea. Injured epithelial basement membrane and hemidesmosomes and edematous collagen fibril bundles resulting from alkali-burned mouse cornea was repaired by bevacizumab treatment. This study demonstrates that bevacizumab can play an important role in wound healing in the cornea by accelerating the reestablishment of basement membrane integrity that leads to barriers for scar formation.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brodovsky, S. C. / 2000 / Management of alkali burns: an 11-year retrospective review / Ophthalmology 107 : 1829 ~ 1835
Burns, F. R. / 1990 / Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide / Invest. Ophthalmol. Vis. Sci 31 : 107 ~ 114
Cintron, C. / 1981 / Quantitative analysis of collagen from normal developing corneas and corneal scars / Curr. Eye Res 1 : 1 ~ 8
Imanishi, J. / 2000 / Growth factors: importance in wound healing and maintenance of transparency of the cornea / Prog. Retinal. Eye Res 19 : 113 ~ 129
Ishizaki, M. / 1993 / Expression of collagen I, smooth muscle actin, and vimentin during the healing of alkali-burned and lacerated corneas / Invest. Ophthalmol. Vis. Sci 34
Burns, F. R. / 1990 / Inhibition of alkali-induced corneal ulceration and perforation by a thiol peptide / Invest. Ophthalmol. Vis. Sci 31 : 107 ~ 114
Cintron, C. / 1981 / Quantitative analysis of collagen from normal developing corneas and corneal scars / Curr. Eye Res 1 : 1 ~ 8
Imanishi, J. / 2000 / Growth factors: importance in wound healing and maintenance of transparency of the cornea / Prog. Retinal. Eye Res 19 : 113 ~ 129
Ishizaki, M. / 1993 / Expression of collagen I, smooth muscle actin, and vimentin during the healing of alkali-burned and lacerated corneas / Invest. Ophthalmol. Vis. Sci 34
이 논문의 저자 정보
최근 본 자료
댓글(0)
0