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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 371 - 376 (6page)
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초록· 키워드
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To investigate the therapeutic effect of a Korean herbal medicine Pulsatilla koreana as an anti-septic agent, anti-inflammatory effects of the herbal medicine were determined in lipopolysaccharide (LPS)-exposed rats. Treatment with a methanol extract from Pulsatilla koreana significantly inhibited LPS-induced inflammatory responses. Results from ELISA analysis showed that Pulsatilla koreana decreased the plasma and hepatic levels of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α while increased the level of anti-inflammatory cytokine IL-10 in LPS-exposed rats. Pulsatilla koreana also decreased the plasma levels of other inflammatory mediators such as NO3-/NO2-,ICAM-1, PGE2, and CINC-1 in LPS-exposed rats. Although no significant effects were observed in the phagocytic activities, the distribution of lymphocyte population was significantly shifted by the treatment with Pulsatilla koreana. All together, Pulsatilla koreana exerts anti-inflammatory activities in the immunechallenged animals implicating that this Korean herbal medicine is therapeutically useful for the treatment of inflammatory diseases like sepsis. [BMB Reports 2012; 45(6): 371-376]
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참고문헌 (23)
참고문헌 신청
Aono, K. / 1997 / In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines / J. Cell. Biochem. 65 :
Ayala, A. / 1994 / Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production / J. Su
Bang, S. C. / 2005 / Triterpenoid saponins from the roots of Pulsatilla koreana / J. Nat. Prod. 68 : 268 ~ 272
Barton, C. C. / 2001 / Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha / Hepatology 33 :
Belvisi, M. G. / 2001 / New Glucocorticosteroids with an improved therapeutic ratio / Pulm. Pharmacol. Ther. 14 : 221 ~ 227
Ayala, A. / 1994 / Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2/IFN-gamma release while increasing IL-4/IL-10 production / J. Su
Bang, S. C. / 2005 / Triterpenoid saponins from the roots of Pulsatilla koreana / J. Nat. Prod. 68 : 268 ~ 272
Barton, C. C. / 2001 / Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha / Hepatology 33 :
Belvisi, M. G. / 2001 / New Glucocorticosteroids with an improved therapeutic ratio / Pulm. Pharmacol. Ther. 14 : 221 ~ 227
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