지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 365 - 370 (6page)
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Hepatitis B virus (HBV) DNA is often integrated into hepatocellular carcinoma (HCC). Although the relationship between HBV integration and HCC development has been widely studied, the role of HBV integration in HCC development is still not completely understood. In the present study, we constructed a pooled BAC library of 9 established cell lines derived from HCC patients with HBV infections. By amplifying viral genes and superpooling of BAC clones, we identified 2 clones harboring integrated HBV DNA. Screening of host-virus junctions by repeated sequencing revealed an HBV DNA integration site on chromosome 11q13 in the SNU-886 cell line. The structure and rearrangement of integrated HBV DNA were extensively analyzed. An inverted duplicated structure, with fusion of at least 2 HBV DNA molecules in opposite orientations, was identified in the region. The gene expression of cancer-related genes increased near the viral integration site in HCC cell line SNU-886. [BMB Reports 2012; 45(6): 365-370]
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참고문헌 (23)
참고문헌 신청
Ahn, S. H. / 2010 / Molecular and Clinical Characteristics of Hepatitis B Virus in Korea / Journal Of Medical Virology 82 (7) : 1126 ~ 1134
Bonilla Guerrero, R. / 2005 / The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma / J. Hepatol. 42 : 760 ~ 777
Brechot, C. / 2004 / Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms / Gastroenterology 127 : S56 ~ S61
Chen, C. F. / 2010 / Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma / Hepatology 52 : 169
Feitelson, M. A. / 2007 / Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis / Cancer. Lett. 252 : 157 ~ 170
Bonilla Guerrero, R. / 2005 / The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma / J. Hepatol. 42 : 760 ~ 777
Brechot, C. / 2004 / Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms / Gastroenterology 127 : S56 ~ S61
Chen, C. F. / 2010 / Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma / Hepatology 52 : 169
Feitelson, M. A. / 2007 / Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis / Cancer. Lett. 252 : 157 ~ 170
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